Bone mineral loss through increased bone turnover in HIV-infected children treated with highly active antiretroviral therapy

Stefano Mora, Natascia Sala, Dorella Bricalli, Giovanna Zuin, Giuseppe Chiumello, Alessandra Viganò

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate the occurrence and define the aetiology of osteopenia in children receiving highly active antiretroviral therapy (HAART). Methods: Bone mineral density (BMD) of total body and lumbar spine (L2-L4) was assessed by dual-energy X-ray absorptiometry in 40 children vertically infected with HIV: 35 taking HAART and five naive to any antiretroviral treatment (untreated). Six HAART-treated children showed clinical evidence of lipodystrophy. N-terminal propeptide of type-I procollagen (PINP), bone-specific alkaline phosphatase (BALP) and N-terminal telopeptide of type I collagen (NTx) were measured. Results were compared with those obtained in 314 healthy controls. Differences between HIV-positive and healthy children and within the HIV-positive group were assessed by multivariate analyses, controlling for confounding variables (age, sex, weight and height). Results: HAART-treated children showed lower spine BMD values than untreated (P=0.045) and healthy (P=0.004) children and lower total body BMD values than untreated (P=0.012) and healthy (P

Original languageEnglish
Pages (from-to)1823-1829
Number of pages7
JournalAIDS (London, England)
Volume15
Issue number14
DOIs
Publication statusPublished - Sep 28 2001

Keywords

  • Bone densitometry
  • Bone mineral metabolism
  • HAART
  • Highly active antiretroviral therapy
  • Lipodystrophy
  • Vertical HIV infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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