Bone niches, hematopoietic stem cells, and vessel formation

Roberto Tamma, Domenico Ribatti

Research output: Contribution to journalReview articlepeer-review


Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche. HSCs give rise to all types of mature blood cells through a process finely controlled by numerous signals emerging from the bone marrow niches where HSCs reside. This review will focus on the description of the role of BM niches in the control of the fate of HSCs and will also highlight the role of the BM niches in the regulation of vasculogenesis and angiogenesis. Moreover, alterations of the signals in niche microenvironment are involved in many aspects of tumor progression and vascularization and further knowledge could provide the basis for the development of new therapeutic strategies.

Original languageEnglish
Article numberE151
Number of pages13
JournalInternational Journal of Molecular Sciences
Issue number1
Publication statusPublished - Jan 13 2017


  • Angiogenesis
  • Bone marrow
  • Endosteal niche
  • Hematopoietic stem cells
  • Vascular niche
  • Vasculogenesis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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