Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties

Stefania Grandi, Valentina Cassinelli, Marcella Bini, Enrica Saino, Piercarlo Mustarelli, Carla Renata Arciola, Marcello Imbriani, Livia Visai

Research output: Contribution to journalArticle

Abstract

Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.

Original languageEnglish
Pages (from-to)920-928
Number of pages9
JournalInternational Journal of Artificial Organs
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Antibacterial activity
  • Bioglass
  • Gold nanoparticles
  • Sol-gel

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

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