Bone reconstruction

Au nanocomposite bioglasses with antibacterial properties

Stefania Grandi, Valentina Cassinelli, Marcella Bini, Enrica Saino, Piercarlo Mustarelli, Carla Renata Arciola, Marcello Imbriani, Livia Visai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.

Original languageEnglish
Pages (from-to)920-928
Number of pages9
JournalInternational Journal of Artificial Organs
Volume34
Issue number9
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Nanocomposites
Bioactive glass
Bone
Doping (additives)
Bactericides
Bone and Bones
Gold
Nanoparticles
Escherichia coli
Glass
Staphylococcus aureus
Bacteria
Anti-Bacterial Agents
Imaging techniques
Bioglass

Keywords

  • Antibacterial activity
  • Bioglass
  • Gold nanoparticles
  • Sol-gel

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

Bone reconstruction : Au nanocomposite bioglasses with antibacterial properties. / Grandi, Stefania; Cassinelli, Valentina; Bini, Marcella; Saino, Enrica; Mustarelli, Piercarlo; Arciola, Carla Renata; Imbriani, Marcello; Visai, Livia.

In: International Journal of Artificial Organs, Vol. 34, No. 9, 09.2011, p. 920-928.

Research output: Contribution to journalArticle

Grandi, Stefania ; Cassinelli, Valentina ; Bini, Marcella ; Saino, Enrica ; Mustarelli, Piercarlo ; Arciola, Carla Renata ; Imbriani, Marcello ; Visai, Livia. / Bone reconstruction : Au nanocomposite bioglasses with antibacterial properties. In: International Journal of Artificial Organs. 2011 ; Vol. 34, No. 9. pp. 920-928.
@article{b6937a1a1eb0486da571abf0f5dad404,
title = "Bone reconstruction: Au nanocomposite bioglasses with antibacterial properties",
abstract = "Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1{\%} wt. and 1{\%} wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.",
keywords = "Antibacterial activity, Bioglass, Gold nanoparticles, Sol-gel",
author = "Stefania Grandi and Valentina Cassinelli and Marcella Bini and Enrica Saino and Piercarlo Mustarelli and Arciola, {Carla Renata} and Marcello Imbriani and Livia Visai",
year = "2011",
month = "9",
doi = "10.5301/ijao.5000059",
language = "English",
volume = "34",
pages = "920--928",
journal = "International Journal of Artificial Organs",
issn = "0391-3988",
publisher = "Wichtig Publishing",
number = "9",

}

TY - JOUR

T1 - Bone reconstruction

T2 - Au nanocomposite bioglasses with antibacterial properties

AU - Grandi, Stefania

AU - Cassinelli, Valentina

AU - Bini, Marcella

AU - Saino, Enrica

AU - Mustarelli, Piercarlo

AU - Arciola, Carla Renata

AU - Imbriani, Marcello

AU - Visai, Livia

PY - 2011/9

Y1 - 2011/9

N2 - Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.

AB - Bioglasses are of wide interest since they spontaneously bond and integrate with living bone in the body. By varying the glass chemistry and/or by adding some dopants, it is possible to improve their clinical applications. Gold nanoparticles (Au NPs) are a well-known antibacterial agent, as well as a unique probe for sensing and imaging applications. We report on the synthesis of a 58S bioglass doped with Au NPs at two doping levels: 0.1% wt. and 1% wt. Antibacterial properties were observed on the Gram-positive Staphylococcus aureus, whereas no significant effects were found on the Gram-negative Escherichia coli. A possible mechanism of action of Au NPs towards bacteria has been described.

KW - Antibacterial activity

KW - Bioglass

KW - Gold nanoparticles

KW - Sol-gel

UR - http://www.scopus.com/inward/record.url?scp=81355136167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81355136167&partnerID=8YFLogxK

U2 - 10.5301/ijao.5000059

DO - 10.5301/ijao.5000059

M3 - Article

VL - 34

SP - 920

EP - 928

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

IS - 9

ER -