Bone regeneration potential of a soybean-based filler: Experimental study in a rabbit cancellous bone defects

Gianluca Giavaresi, Milena Fini, Jonathan Salvage, Nicolò Nicoli Aldini, Roberto Giardino, Luigi Ambrosio, Luigi Nicolais, Matteo Santin

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous and allogenic bone grafts are considered as materials of choice for bone reconstructive surgery, but limited availability, risks of transmittable diseases and inconsistent clinical performances have prompted the development of alternative biomaterials. The present work compares the bone regeneration potential of a soybean based bone filler (SB bone filler) in comparison to a commercial 50:50 poly(d,l lactide-glycolide)-based bone graft (Fisiograft® gel) when implanted into a critical size defect (6-mm diameter, 10-mm length) in rabbit distal femurs. The histomorphometric and microhardness analyses of femoral condyles 4, 8, 16 and 24 weeks after surgery showed that no significant difference was found in the percentage of both bone repair and bone in-growth in the external, medium and inner defect areas. The SB filler-treated defects showed significantly higher outer bone formation and microhardness results at 24 weeks than Fisiograft® gel (P <0.05). Soybean-based biomaterials clearly promoted bone repair through a mechanism of action that is likely to involve both the scaffolding role of the biomaterial for osteoblasts and the induction of their differentiation.

Original languageEnglish
Pages (from-to)615-626
Number of pages12
JournalJournal of Materials Science: Materials in Medicine
Volume21
Issue number2
DOIs
Publication statusPublished - Feb 2010

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering

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