TY - JOUR
T1 - Bone regeneration potential of a soybean-based filler
T2 - Experimental study in a rabbit cancellous bone defects
AU - Giavaresi, Gianluca
AU - Fini, Milena
AU - Salvage, Jonathan
AU - Nicoli Aldini, Nicolò
AU - Giardino, Roberto
AU - Ambrosio, Luigi
AU - Nicolais, Luigi
AU - Santin, Matteo
PY - 2010/2
Y1 - 2010/2
N2 - Autologous and allogenic bone grafts are considered as materials of choice for bone reconstructive surgery, but limited availability, risks of transmittable diseases and inconsistent clinical performances have prompted the development of alternative biomaterials. The present work compares the bone regeneration potential of a soybean based bone filler (SB bone filler) in comparison to a commercial 50:50 poly(d,l lactide-glycolide)-based bone graft (Fisiograft® gel) when implanted into a critical size defect (6-mm diameter, 10-mm length) in rabbit distal femurs. The histomorphometric and microhardness analyses of femoral condyles 4, 8, 16 and 24 weeks after surgery showed that no significant difference was found in the percentage of both bone repair and bone in-growth in the external, medium and inner defect areas. The SB filler-treated defects showed significantly higher outer bone formation and microhardness results at 24 weeks than Fisiograft® gel (P <0.05). Soybean-based biomaterials clearly promoted bone repair through a mechanism of action that is likely to involve both the scaffolding role of the biomaterial for osteoblasts and the induction of their differentiation.
AB - Autologous and allogenic bone grafts are considered as materials of choice for bone reconstructive surgery, but limited availability, risks of transmittable diseases and inconsistent clinical performances have prompted the development of alternative biomaterials. The present work compares the bone regeneration potential of a soybean based bone filler (SB bone filler) in comparison to a commercial 50:50 poly(d,l lactide-glycolide)-based bone graft (Fisiograft® gel) when implanted into a critical size defect (6-mm diameter, 10-mm length) in rabbit distal femurs. The histomorphometric and microhardness analyses of femoral condyles 4, 8, 16 and 24 weeks after surgery showed that no significant difference was found in the percentage of both bone repair and bone in-growth in the external, medium and inner defect areas. The SB filler-treated defects showed significantly higher outer bone formation and microhardness results at 24 weeks than Fisiograft® gel (P <0.05). Soybean-based biomaterials clearly promoted bone repair through a mechanism of action that is likely to involve both the scaffolding role of the biomaterial for osteoblasts and the induction of their differentiation.
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U2 - 10.1007/s10856-009-3870-6
DO - 10.1007/s10856-009-3870-6
M3 - Article
C2 - 19771493
AN - SCOPUS:77951256624
VL - 21
SP - 615
EP - 626
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 2
ER -