Bone tissue engineering: Natural origination or synthetic polymeric scaffolds?

Serena Danti, Michele Lisanti, Stefano Berrettini, Mario Petrini, Andrea Pietrabissa

Research output: Contribution to journalArticle

Abstract

The aim of this report was to investigate the behavior of human mesenchymal stem cells (hMSCs) when cultured on different porous 3D scaffolds, having natural or synthetic origination. Natural scaffolds were obtained by hand made processing of human bone tissue (allograft), because its well known osteoconductive features, using different procedures to eliminate the donor cellular phase. Cancellous bone was frozen, heated or demineralized before being loaded with hMSCs. Among the variety of synthetic materials, biodegradable polymeric spongy matrices were chosen and comparatively tested as scaffolds for hMSCs growth.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalAdvanced Materials Research
Volume15-17
Publication statusPublished - 2007

Keywords

  • Bone tissue engineering
  • Cancellous bone grafts
  • Demineralized bone matrix
  • Mesenchymal stem cells
  • Polymeric scaffolds

ASJC Scopus subject areas

  • Engineering(all)

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