Bones in coeliac disease: Diagnosis and treatment

Gino Roberto Corazza, Michele Di Stefano, Eduardo Mauriño, Julio C. Bai

Research output: Contribution to journalArticlepeer-review

Abstract

Coeliac disease predisposes to metabolic osteopathy. The entity of bone loss is higher in patients with malabsorption at diagnosis but it is also present in asymptomatic or poorly symptomatic patients, occurring in roughly half of them. Calcium malabsorption and the release of proinflammatory cytokines, activating osteoclasts, represent the main mechanisms responsible for bone derangement. In coeliacs, the presence of an increased fracture risk was recently questioned and its importance on clinical grounds was reconsidered, in view of the fact that gluten-free diet generally improves bone mass and, consequently, reduces fracture risk. However, gluten-free diet rarely normalizes bone mass and the co-administration of mineral active drugs may be useful in a subgroup of coeliacs.

Original languageEnglish
Pages (from-to)453-465
Number of pages13
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Volume19
Issue number3 SPEC. ISS.
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Bone densitometry
  • Bone mineral density
  • Coeliac disease
  • Gluten-free diet
  • Osteopenia
  • Osteoporosis

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Bones in coeliac disease: Diagnosis and treatment'. Together they form a unique fingerprint.

Cite this