TY - JOUR
T1 - Bones in coeliac disease
T2 - Diagnosis and treatment
AU - Corazza, Gino Roberto
AU - Di Stefano, Michele
AU - Mauriño, Eduardo
AU - Bai, Julio C.
PY - 2005/6
Y1 - 2005/6
N2 - Coeliac disease predisposes to metabolic osteopathy. The entity of bone loss is higher in patients with malabsorption at diagnosis but it is also present in asymptomatic or poorly symptomatic patients, occurring in roughly half of them. Calcium malabsorption and the release of proinflammatory cytokines, activating osteoclasts, represent the main mechanisms responsible for bone derangement. In coeliacs, the presence of an increased fracture risk was recently questioned and its importance on clinical grounds was reconsidered, in view of the fact that gluten-free diet generally improves bone mass and, consequently, reduces fracture risk. However, gluten-free diet rarely normalizes bone mass and the co-administration of mineral active drugs may be useful in a subgroup of coeliacs.
AB - Coeliac disease predisposes to metabolic osteopathy. The entity of bone loss is higher in patients with malabsorption at diagnosis but it is also present in asymptomatic or poorly symptomatic patients, occurring in roughly half of them. Calcium malabsorption and the release of proinflammatory cytokines, activating osteoclasts, represent the main mechanisms responsible for bone derangement. In coeliacs, the presence of an increased fracture risk was recently questioned and its importance on clinical grounds was reconsidered, in view of the fact that gluten-free diet generally improves bone mass and, consequently, reduces fracture risk. However, gluten-free diet rarely normalizes bone mass and the co-administration of mineral active drugs may be useful in a subgroup of coeliacs.
KW - Bone densitometry
KW - Bone mineral density
KW - Coeliac disease
KW - Gluten-free diet
KW - Osteopenia
KW - Osteoporosis
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U2 - 10.1016/j.bpg.2005.01.002
DO - 10.1016/j.bpg.2005.01.002
M3 - Article
C2 - 15925849
AN - SCOPUS:19944383846
VL - 19
SP - 453
EP - 465
JO - Bailliere's Best Practice and Research in Clinical Gastroenterology
JF - Bailliere's Best Practice and Research in Clinical Gastroenterology
SN - 1521-6918
IS - 3 SPEC. ISS.
ER -