Boosted protease inhibitor-including versus a protease inhibitor-sparing regimen in protease inhibitor-resistant HIV-infected patients: 24-week immunological outcome

Nicola Gianotti, Alessandro Soria, Laura Galli, Barbara Giudici, Giuliana Fusetti, Adriano Lazzarin, Enzo Boeri, Antonella Castagna

Research output: Contribution to journalArticle


The best salvage therapy for protease inhibitor (PI)-resistant HIV-infected patients is still controversial. We measured changes in viral load and CD4 T-lymphocyte counts in 40 PI-resistant patients receiving boosted PI-including or PI-sparing antiretroviral therapy. At multivariate analysis, the only independent predictor of CD4 T-lymphocyte changes at week 24 was a boosted PI-including regimen. In PI-resistant HIV-infected patients, a boosted PI regimen preserves CD4 T lymphocytes from depletion in the medium term compared with a PI-sparing regimen.

Original languageEnglish
Pages (from-to)821-823
Number of pages3
JournalAIDS (London, England)
Issue number5
Publication statusPublished - Mar 26 2004


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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