Borrelia burgdorferi infection and Lyme disease in children

Susanna Esposito, Samantha Bosis, Caterina Sabatini, Laura Tagliaferri, Nicola Principi

Research output: Contribution to journalArticlepeer-review


Lyme disease is a multisystem disease that frequently affects children. It is caused by a group of related spirochetes, Borrelia burgdorferi sensu lato, that are transmitted by ticks belonging to species of the genus Ixodes. The clinical characteristics of Lyme disease in pediatrics resemble those observed in adults, although the symptoms may last for a shorter time and the outcome may be better. However, identifying Lyme disease in children can be significantly more difficult because some of its signs and symptoms can be similar to those of other common pediatric clinical manifestations. Finally, the diagnostic and therapeutic approach to childhood Lyme disease is frequently not codified, and guidelines specifically prepared for adults are used for children without having been validated. This review of the currently available data will evaluate what may be the best approach to the diagnosis and treatment of B. burgdorferi infection and disease in the pediatric population.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Issue number3
Publication statusPublished - Mar 2013


  • Borrelia burgdorferi
  • Erythema migrans
  • Heart borreliosis
  • Lyme arthritis
  • Lyme disease
  • Lyme meningitis
  • Neuroborreliosis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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