Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma: Clinical and molecular analyses of a phase 3 study

Paola Tacchetti; Carolina Terragna; Monica Galli; Elena Zamagni; Maria Teresa Petrucci; Annalisa Pezzi; Vittorio Montefusco; Marina Martello; Patrizia Tosi; Luca Baldini; Jacopo Peccatori; Miriana Ruggieri; Lucia Pantani; Antonio Lazzaro; Francesca Elice; Serena Rocchi; Alessandro Gozzetti; Guido Cavaletti; Antonio Palumbo; Michele Cavo

doi:10.1002/ajh.23835

Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma: Clinical and molecular analyses of a phase 3 study

Paola Tacchetti, Carolina Terragna, Monica Galli, Elena Zamagni, Maria Teresa Petrucci, Annalisa Pezzi, Vittorio Montefusco, Marina Martello, Patrizia Tosi, Luca Baldini, Jacopo Peccatori, Miriana Ruggieri, Lucia Pantani, Antonio Lazzaro, Francesca Elice, Serena Rocchi, Alessandro Gozzetti, Guido Cavaletti, Antonio Palumbo, Michele Cavo

Research output: Contribution to journal › Article › peer-review

Abstract

A subanalysis of the GIMEMA-MMY-3006 trial was performed to characterize treatment-emergent peripheral neuropathy (PN) in patients randomized to thalidomide-dexamethasone (TD) or bortezomib-TD (VTD) before and after double autologous transplantation (ASCT) for multiple myeloma (MM). A total of 236 patients randomized to VTD and 238 to TD were stratified according to the emergence of grade ≥2 PN. Gene expression profiles (GEP) of CD138+ plasma cells were analyzed in 120 VTD-treated patients. The incidence of grade ≥2 PN was 35% in the VTD arm and 10% in the TD arm (P

Original language	English
Pages (from-to)	1085-1091
Number of pages	7
Journal	American Journal of Hematology
Volume	89
Issue number	12
DOIs	https://doi.org/10.1002/ajh.23835
Publication status	Published - Dec 1 2014

ASJC Scopus subject areas

Hematology
Medicine(all)

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Tacchetti, P., Terragna, C., Galli, M., Zamagni, E., Petrucci, M. T., Pezzi, A., Montefusco, V., Martello, M., Tosi, P., Baldini, L., Peccatori, J., Ruggieri, M., Pantani, L., Lazzaro, A., Elice, F., Rocchi, S., Gozzetti, A., Cavaletti, G., Palumbo, A., & Cavo, M. (2014). Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma: Clinical and molecular analyses of a phase 3 study. American Journal of Hematology, 89(12), 1085-1091. https://doi.org/10.1002/ajh.23835

Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma : Clinical and molecular analyses of a phase 3 study. / Tacchetti, Paola; Terragna, Carolina; Galli, Monica; Zamagni, Elena; Petrucci, Maria Teresa; Pezzi, Annalisa; Montefusco, Vittorio; Martello, Marina; Tosi, Patrizia; Baldini, Luca ; Peccatori, Jacopo; Ruggieri, Miriana; Pantani, Lucia; Lazzaro, Antonio; Elice, Francesca; Rocchi, Serena; Gozzetti, Alessandro; Cavaletti, Guido; Palumbo, Antonio; Cavo, Michele.

In: American Journal of Hematology, Vol. 89, No. 12, 01.12.2014, p. 1085-1091.

Research output: Contribution to journal › Article › peer-review

Tacchetti, P, Terragna, C, Galli, M, Zamagni, E, Petrucci, MT, Pezzi, A, Montefusco, V, Martello, M, Tosi, P, Baldini, L , Peccatori, J, Ruggieri, M, Pantani, L, Lazzaro, A, Elice, F, Rocchi, S, Gozzetti, A, Cavaletti, G, Palumbo, A & Cavo, M 2014, 'Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma: Clinical and molecular analyses of a phase 3 study', American Journal of Hematology, vol. 89, no. 12, pp. 1085-1091. https://doi.org/10.1002/ajh.23835

Tacchetti, Paola ; Terragna, Carolina ; Galli, Monica ; Zamagni, Elena ; Petrucci, Maria Teresa ; Pezzi, Annalisa ; Montefusco, Vittorio ; Martello, Marina ; Tosi, Patrizia ; Baldini, Luca ; Peccatori, Jacopo ; Ruggieri, Miriana ; Pantani, Lucia ; Lazzaro, Antonio ; Elice, Francesca ; Rocchi, Serena ; Gozzetti, Alessandro ; Cavaletti, Guido ; Palumbo, Antonio ; Cavo, Michele. / Bortezomib- and thalidomide-induced peripheral neuropathy in multiple myeloma : Clinical and molecular analyses of a phase 3 study. In: American Journal of Hematology. 2014 ; Vol. 89, No. 12. pp. 1085-1091.

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abstract = "A subanalysis of the GIMEMA-MMY-3006 trial was performed to characterize treatment-emergent peripheral neuropathy (PN) in patients randomized to thalidomide-dexamethasone (TD) or bortezomib-TD (VTD) before and after double autologous transplantation (ASCT) for multiple myeloma (MM). A total of 236 patients randomized to VTD and 238 to TD were stratified according to the emergence of grade ≥2 PN. Gene expression profiles (GEP) of CD138+ plasma cells were analyzed in 120 VTD-treated patients. The incidence of grade ≥2 PN was 35% in the VTD arm and 10% in the TD arm (P",

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