Bortezomib plus dexamethasone can improve stem cell collection and overcome the need for additional chemotherapy before autologous transplant in patients with myeloma

Alessandro Corso, Luciana Barbarano, Silvia Mangiacavalli, Mauro Spriano, Emilio P. Alessandrino, Anna Maria Cafro, Cristiana Pascutto, Marzia Varettoni, Paolo Bernasconi, Giovanni Grillo, Angelo M. Carella, Luigi Montalbetti, Mario Lazzarino, Enrica Morra

Research output: Contribution to journalArticle

Abstract

The aim of this phase II trial was to investigate the efficacy of bortezomib plus dexamethasone (Vel-Dex) as induction therapy in patients with multiple myeloma (MM) and to define the role of intensification before transplantation. Fifty-seven patients were treated with four courses of Vel-Dex, two cycles of dexamethasone, cyclophosphamide, etoposide and cisplatin (DCEP), and a single autologous transplant. Fourteen patients (25) went off-study: seven after Vel-Dex, seven after DCEP. All patients yielded high numbers of stem cells (median CD34 cells 7.5×106/kg); 54 of the 57 patients (94) collected ≥4×106/kg CD34 cells, 60 with a single leukapheresis. The overall response rate (ORR) after Vel-Dex was 86 (70 had a very good partial response [VGPR] or better) regardless of cytogenetic abnormalities and International Staging System stage (ISS). The response at the end of the two DCEP cycles remained unchanged in 35 patients (70), worsened in 15 (20), and improved in 5 (10). Because of the consistent drop-out, the ORR in intention-to-treat analysis decreased significantly from 86 after Vel-Dex to 76 after DCEP, and 73 after transplantation. However, when considering the subset of 43 patients who completed the program, the ORR was 96 (complete response 39, VGPR 41, partial response 16). In conclusion, Vel-Dex produces high response rates, improves stem cell collection, and overcomes the need for intensification before autologous transplantation.

Original languageEnglish
Pages (from-to)236-242
Number of pages7
JournalLeukemia and Lymphoma
Volume51
Issue number2
DOIs
Publication statusPublished - Feb 2010

    Fingerprint

Keywords

  • Bortezomib
  • DCEP
  • High-dose therapy
  • Induction therapy
  • Multiple myeloma
  • Peripheral stem cell collection

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this