Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial)

Elisabetta Bacchi, Carlo Negri, Giovanni Targher, Niccolò Faccioli, Massimo Lanza, Giacomo Zoppini, Elisabetta Zanolin, Federico Schena, Enzo Bonora, Paolo Moghetti

Research output: Contribution to journalArticle

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Abstract

Although lifestyle interventions are considered the first-line therapy for nonalcoholic fatty liver disease (NAFLD), which is extremely common in people with type 2 diabetes, no intervention studies have compared the effects of aerobic (AER) or resistance (RES) training on hepatic fat content in type 2 diabetic subjects with NAFLD. In this randomized controlled trial, we compared the 4-month effects of either AER or RES training on insulin sensitivity (by hyperinsulinemic euglycemic clamp), body composition (by dual-energy X-ray absorptiometry), as well as hepatic fat content and visceral (VAT), superficial (SSAT), and deep (DSAT) subcutaneous abdominal adipose tissue (all quantified by an in-opposed-phase magnetic resonance imaging technique) in 31 sedentary adults with type 2 diabetes and NAFLD. After training, hepatic fat content was markedly reduced (P5.56%) disappeared in about one-quarter of the patients in each intervention group (23.1% in the AER group and 23.5% in the RES group). Insulin sensitivity during euglycemic clamp was increased, whereas total body fat mass, VAT, SSAT, and hemoglobin A1c were reduced comparably in both intervention groups. Conclusion: This is the first randomized controlled study to demonstrate that resistance training and aerobic training are equally effective in reducing hepatic fat content among type 2 diabetic patients with NAFLD.

Original languageEnglish
Pages (from-to)1287-1295
Number of pages9
JournalHepatology
Volume58
Issue number4
DOIs
Publication statusPublished - Oct 2013

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Resistance Training
Fats
Glucose Clamp Technique
Liver
Type 2 Diabetes Mellitus
Insulin Resistance
Abdominal Subcutaneous Fat
Intra-Abdominal Fat
Photon Absorptiometry
Body Composition
Adipose Tissue
Life Style
Hemoglobins
Randomized Controlled Trials
Magnetic Resonance Imaging
Non-alcoholic Fatty Liver Disease
Therapeutics

ASJC Scopus subject areas

  • Hepatology

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Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial). / Bacchi, Elisabetta; Negri, Carlo; Targher, Giovanni; Faccioli, Niccolò; Lanza, Massimo; Zoppini, Giacomo; Zanolin, Elisabetta; Schena, Federico; Bonora, Enzo; Moghetti, Paolo.

In: Hepatology, Vol. 58, No. 4, 10.2013, p. 1287-1295.

Research output: Contribution to journalArticle

Bacchi, Elisabetta ; Negri, Carlo ; Targher, Giovanni ; Faccioli, Niccolò ; Lanza, Massimo ; Zoppini, Giacomo ; Zanolin, Elisabetta ; Schena, Federico ; Bonora, Enzo ; Moghetti, Paolo. / Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 randomized trial). In: Hepatology. 2013 ; Vol. 58, No. 4. pp. 1287-1295.
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