TY - JOUR
T1 - Botulinum toxin a in postherpetic neuralgia
T2 - A parallel, randomized, double-blind, single-dose, placebo-controlled trial
AU - Apalla, Zoe
AU - Sotiriou, Elena
AU - Lallas, Aimilios
AU - Lazaridou, Elizabeth
AU - Ioannides, Demetrios
PY - 2013/10
Y1 - 2013/10
N2 - Objectives: Cumulative evidence support a beneficial effect of botulinum toxin A (BTX-A) in postherpetic neuralgia (PHN). We aimed to assess efficacy, safety, and tolerability of BTX-A in the management of PHN, performing a randomized, double-blind, single-dose, placebo-controlled trial. Methods: Thirty adults with PHN were randomized either to BTXA or placebo. Severity of pain was evaluated by patients using a visual analogue scale (VAS) and quality of sleep was assessed using a 5-item questionnaire. Primary outcome was reduction in VAS score, with a greater than 50% reduction being considered clinically significant. Secondary outcomes were reduction in sleep score and maintenance of VAS score after treatment, with over 50% maintenance considered clinically meaningful. Results: Thirteen patients from the experimental arm achieved an at least 50% reduction in VAS score, compared with none of the placebo patients (NNT=1.2, 95% CI, 2-1; ARR=0.87, 95% CI, 055-096; P
AB - Objectives: Cumulative evidence support a beneficial effect of botulinum toxin A (BTX-A) in postherpetic neuralgia (PHN). We aimed to assess efficacy, safety, and tolerability of BTX-A in the management of PHN, performing a randomized, double-blind, single-dose, placebo-controlled trial. Methods: Thirty adults with PHN were randomized either to BTXA or placebo. Severity of pain was evaluated by patients using a visual analogue scale (VAS) and quality of sleep was assessed using a 5-item questionnaire. Primary outcome was reduction in VAS score, with a greater than 50% reduction being considered clinically significant. Secondary outcomes were reduction in sleep score and maintenance of VAS score after treatment, with over 50% maintenance considered clinically meaningful. Results: Thirteen patients from the experimental arm achieved an at least 50% reduction in VAS score, compared with none of the placebo patients (NNT=1.2, 95% CI, 2-1; ARR=0.87, 95% CI, 055-096; P
KW - Botulinum toxin
KW - Herpes zoster
KW - Neuropathic pain
KW - Postherpetic neuralgia
KW - Randomized clinical trial
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U2 - 10.1097/AJP.0b013e31827a72d2
DO - 10.1097/AJP.0b013e31827a72d2
M3 - Article
C2 - 23370074
AN - SCOPUS:84888005745
VL - 29
SP - 857
EP - 864
JO - Clinical Journal of Pain
JF - Clinical Journal of Pain
SN - 0749-8047
IS - 10
ER -