Botulinum toxin and neuromotor rehabilitation: An integrated appraoch to idiopathic cervical dystonia

Cristina Tassorelli, Francesca Mancini, Laura Balloni, Claudio Pacchetti, Giorgio Sandiri, Giuseppe Nappi, Emilia Martignoni

Research output: Contribution to journalArticlepeer-review

Abstract

Currently, the best treatment option for idiopathic cervical dystonia (ICD) is injection of botulinum toxin (BTX) into the affected muscles, whereas rehabilitative approaches have given disappointing results. We evaluated whether the association of an ad hoc rehabilitative program may improve the clinical efficacy of BTX treatment in a single-center, cross-over, controlled study. Forty patients with ICD were randomly assigned to two different treatment groups: (1) BTX type A (BTX-A) plus a specific program of physical therapy (BTX-PT) or (2) BTX-A alone (BTX-0). Patients in the BTX-PT group showed a longer duration of the clinical benefit (118.8 vs. 99.1 days) and needed a lower dose of BTX at reinjection (284.5 vs. 325.5 units). In addition, they showed more marked reductions in their disability in activities of daily living (-9.7 vs. -4.85 points) and subjective pain (-13.35 vs. 6.95 points) scores. Association of BTX-A therapy with a specific program of physical therapy may improve ICD treatment outcome.

Original languageEnglish
Pages (from-to)2240-2243
Number of pages4
JournalMovement Disorders
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Biofeedback
  • Botolinum toxin
  • Cervical dystonia
  • Physiotheraphy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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