Botulinum toxin for chronic anal fissure

D. Gui, G. Anastasio, G. Maria, E. Cassetta, A. R. Bentivoglio, A. Albanese

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.

Original languageEnglish
Pages (from-to)1127-1128
Number of pages2
JournalLancet
Volume344
Issue number8930
DOIs
Publication statusPublished - Oct 22 1994

Fingerprint

Fissure in Ano
Botulinum Toxins
Fecal Incontinence
Type A Botulinum Toxins
Injections
Striated Muscle
Anal Canal
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gui, D., Anastasio, G., Maria, G., Cassetta, E., Bentivoglio, A. R., & Albanese, A. (1994). Botulinum toxin for chronic anal fissure. Lancet, 344(8930), 1127-1128. https://doi.org/10.1016/S0140-6736(94)90633-5

Botulinum toxin for chronic anal fissure. / Gui, D.; Anastasio, G.; Maria, G.; Cassetta, E.; Bentivoglio, A. R.; Albanese, A.

In: Lancet, Vol. 344, No. 8930, 22.10.1994, p. 1127-1128.

Research output: Contribution to journalArticle

Gui, D, Anastasio, G, Maria, G, Cassetta, E, Bentivoglio, AR & Albanese, A 1994, 'Botulinum toxin for chronic anal fissure', Lancet, vol. 344, no. 8930, pp. 1127-1128. https://doi.org/10.1016/S0140-6736(94)90633-5
Gui D, Anastasio G, Maria G, Cassetta E, Bentivoglio AR, Albanese A. Botulinum toxin for chronic anal fissure. Lancet. 1994 Oct 22;344(8930):1127-1128. https://doi.org/10.1016/S0140-6736(94)90633-5
Gui, D. ; Anastasio, G. ; Maria, G. ; Cassetta, E. ; Bentivoglio, A. R. ; Albanese, A. / Botulinum toxin for chronic anal fissure. In: Lancet. 1994 ; Vol. 344, No. 8930. pp. 1127-1128.
@article{a4c034a0b61e432c939e4cce4807e848,
title = "Botulinum toxin for chronic anal fissure",
abstract = "Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.",
author = "D. Gui and G. Anastasio and G. Maria and E. Cassetta and Bentivoglio, {A. R.} and A. Albanese",
year = "1994",
month = "10",
day = "22",
doi = "10.1016/S0140-6736(94)90633-5",
language = "English",
volume = "344",
pages = "1127--1128",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Lancet Publishing Group",
number = "8930",

}

TY - JOUR

T1 - Botulinum toxin for chronic anal fissure

AU - Gui, D.

AU - Anastasio, G.

AU - Maria, G.

AU - Cassetta, E.

AU - Bentivoglio, A. R.

AU - Albanese, A.

PY - 1994/10/22

Y1 - 1994/10/22

N2 - Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.

AB - Botulinum toxin can chemically denervate striated muscle. Botulinum toxin A (15 U) was used to treat ten patients with chronic anal fissure by injection in the internal sphincter. In seven patients, the lesion healed at 2 months after treatment; one relapsed at 3 months. In one patient the lesion healed at 1 month, but partly relapsed a month later. Mild faecal incontinence lasting for 1 day was observed in one patient. We propose that botulinum toxin injections in the internal anal sphincter be considered an alternative approach to surgical therapy of anal fissure.

UR - http://www.scopus.com/inward/record.url?scp=0028075586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028075586&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(94)90633-5

DO - 10.1016/S0140-6736(94)90633-5

M3 - Article

C2 - 7934496

AN - SCOPUS:0028075586

VL - 344

SP - 1127

EP - 1128

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8930

ER -