Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure

Long-term results after two different dosage regimens

Giorgio Maria, Giuseppe Brisinda, Anna Rita Bentivoglio, Emanuele Cassetta, Daniele Gui, Alberto Albanese

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Objective: To investigate the effects of two different dosage regimens of botulinum toxin to induce healing in patients with idiopathic anal fissure. Summary Background Data: Chronic anal fissure is maintained by contraction of the internal anal sphincter. Sphincterotomy, which is successful in 85% to 95% of patients, permanently weakens the sphincter and therefore might be associated with anal deformity and incontinence. Methods: Fifty-seven consecutive outpatients were evaluated. Type A botulinum toxin was injected into the internal anal sphincter. Results: Patients were divided into two treatment groups based on the number of botulinum toxin units injected. Patients in the first group were treated with 15 units and retreated with 20 units. Patients in the second group were treated with 20 units and retreated with 25 units. Two months after treatment, 10 patients in the first group and 23 patients in the second group had a healing scar. Symptomatic improvement was observed in 13 patients in the first group and in 24 patients in the second group. Statistical analysis showed that resting anal pressure varied from baseline values as a function of treatment; in contrast, the treatment had no effect on maximum voluntary pressure. Long- term healing was achieved in 13 patients in the first group and in all patients in the second group who underwent a complete treatment. Conclusions: Botulinum toxin is safe and effective in the treatment of anal fissure. It is less expensive and easier to perform than surgical treatment. No adverse effects resulted from injections of the toxin. The higher dosage is effective in producing long-term healing without complications.

Original languageEnglish
Pages (from-to)664-669
Number of pages6
JournalAnnals of Surgery
Volume228
Issue number5
DOIs
Publication statusPublished - Nov 1998

Fingerprint

Fissure in Ano
Botulinum Toxins
Anal Canal
Injections
Therapeutics
Pressure
Type A Botulinum Toxins
Cicatrix
Outpatients

ASJC Scopus subject areas

  • Surgery

Cite this

Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure : Long-term results after two different dosage regimens. / Maria, Giorgio; Brisinda, Giuseppe; Bentivoglio, Anna Rita; Cassetta, Emanuele; Gui, Daniele; Albanese, Alberto.

In: Annals of Surgery, Vol. 228, No. 5, 11.1998, p. 664-669.

Research output: Contribution to journalArticle

Maria, Giorgio ; Brisinda, Giuseppe ; Bentivoglio, Anna Rita ; Cassetta, Emanuele ; Gui, Daniele ; Albanese, Alberto. / Botulinum toxin injections in the internal anal sphincter for the treatment of chronic anal fissure : Long-term results after two different dosage regimens. In: Annals of Surgery. 1998 ; Vol. 228, No. 5. pp. 664-669.
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abstract = "Objective: To investigate the effects of two different dosage regimens of botulinum toxin to induce healing in patients with idiopathic anal fissure. Summary Background Data: Chronic anal fissure is maintained by contraction of the internal anal sphincter. Sphincterotomy, which is successful in 85{\%} to 95{\%} of patients, permanently weakens the sphincter and therefore might be associated with anal deformity and incontinence. Methods: Fifty-seven consecutive outpatients were evaluated. Type A botulinum toxin was injected into the internal anal sphincter. Results: Patients were divided into two treatment groups based on the number of botulinum toxin units injected. Patients in the first group were treated with 15 units and retreated with 20 units. Patients in the second group were treated with 20 units and retreated with 25 units. Two months after treatment, 10 patients in the first group and 23 patients in the second group had a healing scar. Symptomatic improvement was observed in 13 patients in the first group and in 24 patients in the second group. Statistical analysis showed that resting anal pressure varied from baseline values as a function of treatment; in contrast, the treatment had no effect on maximum voluntary pressure. Long- term healing was achieved in 13 patients in the first group and in all patients in the second group who underwent a complete treatment. Conclusions: Botulinum toxin is safe and effective in the treatment of anal fissure. It is less expensive and easier to perform than surgical treatment. No adverse effects resulted from injections of the toxin. The higher dosage is effective in producing long-term healing without complications.",
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