Botulinum toxin injections reduce associative plasticity in patients with primary dystonia

Maja Kojovic, Antonio Caronni, Matteo Bologna, John C. Rothwell, Kailash P. Bhatia, Mark J. Edwards

Research output: Contribution to journalArticle

Abstract

Botulinum toxin injections ameliorate dystonic symptoms by blocking the neuromuscular junction and weakening dystonic contractions. We asked if botulinum toxin injections in dystonia patients might also affect the integrity of sensorimotor cortical plasticity, one of the key pathophysiological features of dystonia. We applied a paired associative stimulation protocol, known to induce long-term potentiation-like changes in the primary motor cortex hand area to 12 patients with cervical dystonia before and 1 and 3 months after botulinum toxin injections to the neck muscles. Primary motor cortex excitability was probed by measuring transcranial magnetic stimulation-evoked motor evoked potentials before and after paired associative stimulation. We also measured the input-output curve, short-interval intracortical inhibition, intracortical facilitation, short afferent inhibition, and long afferent inhibition in hand muscles and the clinical severity of dystonia. Before botulinum toxin injections, paired associative stimulation significantly facilitated motor evoked potentials in hand muscles. One month after injections, this effect was abolished, with partial recovery after 3 months. There were significant positive correlations between the facilitation produced by paired associative stimulation and (1) the time elapsed since botulinum toxin injections and (2) the clinical dystonia score. One effect of botulinum toxin injection treatment is to modulate afferent input from the neck. We propose that subsequent reorganization of the motor cortex representation of hand muscles may explain the effect of botulinum toxin on motor cortical plasticity.

Original languageEnglish
Pages (from-to)1282-1289
Number of pages8
JournalMovement Disorders
Volume26
Issue number7
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Dystonic Disorders
Botulinum Toxins
Dystonia
Injections
Motor Cortex
Hand
Motor Evoked Potentials
Muscles
Neck Muscles
Torticollis
Transcranial Magnetic Stimulation
Long-Term Potentiation
Neuromuscular Junction
Neck

Keywords

  • Botulinum toxin
  • Cervical dystonia
  • Cortical plasticity
  • Paired associative stimulation
  • Primary dystonia
  • TMS
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Kojovic, M., Caronni, A., Bologna, M., Rothwell, J. C., Bhatia, K. P., & Edwards, M. J. (2011). Botulinum toxin injections reduce associative plasticity in patients with primary dystonia. Movement Disorders, 26(7), 1282-1289. https://doi.org/10.1002/mds.23681

Botulinum toxin injections reduce associative plasticity in patients with primary dystonia. / Kojovic, Maja; Caronni, Antonio; Bologna, Matteo; Rothwell, John C.; Bhatia, Kailash P.; Edwards, Mark J.

In: Movement Disorders, Vol. 26, No. 7, 06.2011, p. 1282-1289.

Research output: Contribution to journalArticle

Kojovic, M, Caronni, A, Bologna, M, Rothwell, JC, Bhatia, KP & Edwards, MJ 2011, 'Botulinum toxin injections reduce associative plasticity in patients with primary dystonia', Movement Disorders, vol. 26, no. 7, pp. 1282-1289. https://doi.org/10.1002/mds.23681
Kojovic, Maja ; Caronni, Antonio ; Bologna, Matteo ; Rothwell, John C. ; Bhatia, Kailash P. ; Edwards, Mark J. / Botulinum toxin injections reduce associative plasticity in patients with primary dystonia. In: Movement Disorders. 2011 ; Vol. 26, No. 7. pp. 1282-1289.
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