Botulinum toxin type A in the healing of ulcer following oro-mandibular dyskinesia in a patient in a vegetative state

Domenico Intiso, Mario Basciani, Filomena Di Rienzo, Maurizio Tolfa, Giuseppina Grimaldi, Piero Fiore

Research output: Contribution to journalArticle


Objective: Use of botulinum toxin is expanding as clinical studies demonstrate new potential therapeutic applications. In rehabilitation, botulinum toxin is predominantly used as adjunct therapy for the treatment of spasticity, but it may prove useful for other atypical clinical situations. Case history: A 73-year-old man had a severe sub-arachnoid haemorrhage following the rupture of a giant aneurism of the middle left cerebral artery. Clinically, the patient presented a vegetative state and an oro-mandibular dyskinesia that produced a chronic ulcer on the lower lip. As treatment for this dyskinesia, a total of 320 U botulinum toxin type A were injected into the upper and lower orbicularis oris and masseter muscles. Results and Discussion: This treatment allowed for application of topical medication and subsequently, ulcer healing. Botulinum toxin type A may be an important therapeutic aid for clinicians faced with treating persistent pathological conditions caused by dyskinesia.

Original languageEnglish
Pages (from-to)315-316
Number of pages2
JournalJournal of Rehabilitation Medicine
Issue number4
Publication statusPublished - Apr 2008



  • Botulinum toxin type A
  • Dyskinesia
  • Rehabilitation
  • Ulcer
  • Vegetative state

ASJC Scopus subject areas

  • Rehabilitation
  • Health Professions(all)
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Orthopedics and Sports Medicine

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