Bowel contrast-enhanced ultrasound perfusion imaging in the evaluation of Crohn's disease patients undergoing anti-TNFα therapy: Dynamic contrast enhanced ultrasound and treatment response in Crohn disease

Lucrezia Laterza, Maria Elena Ainora, Matteo Garcovich, Linda Galasso, Andrea Poscia, Enrico Di Stasio, Andrea Lupascu, Laura Riccardi, Franco Scaldaferri, Alessandro Armuzzi, Gian Ludovico Rapaccini, Antonio Gasbarrini, Maurizio Pompili, Maria Assunta Zocco

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To evaluate whether changes in bowel perfusion parameters measured by dynamic-CEUS (D-CEUS) can be used for monitoring response to therapy in active Crohn disease (CD). Methods: Fifty-four CD patients were evaluated with D-CEUS before (T0) and after 2 (T1), 6 (T2) and 12 weeks (T3) of anti-TNFα therapy. Variations from baseline were calculated for: peak intensity, PI; area under the curve, AUC; slope of wash in, Pw; time to peak, TP; mean transit time, MTT (median percentage values) and were correlated with combined endoscopic/clinical response after 12 weeks and clinical relapse within 6 months. Results: 70% of patients achieved combined endoscopic/clinical response (responders). The reduction in PI, AUC, Pw and MTT between T1 and T0 was higher in responders. Relapsers (21%) showed significantly lower reduction in delta PI and Pw at T1 and T2. At T3 they showed a new increase in PI and lower reduction in delta Pw. In relapsers, AUC showed a significantly lower decrease at T2 and T3, TP showed a significant reduction at T3 and MTT showed a progressive increase at the different time-points, reaching the statistical significance at T3. Conclusions: D-CEUS might become a reliable predictor of combined endoscopic/clinical response and clinical relapse in CD.

Original languageEnglish
JournalDigestive and Liver Disease
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Crohn
  • Dynamic CEUS
  • Endoscopic remission
  • IBD
  • Response to therapy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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