Bowel function and quality of life after local excision or total mesorectal excision following chemoradiotherapy for rectal cancer

Salvatore Pucciarelli, Francesca Giandomenico, Antonino De Paoli, Teresa Gavaruzzi, Lorella Lotto, Giovanna Mantello, C. Barba, Paola Zotti, S. Flora, Paola Del Bianco

Research output: Contribution to journalArticle

Abstract

Background: Local excision for rectal cancer is expected to offer a better functional outcome than conventional surgery. The aim of the present study was to compare quality of life and bowel function in patients with rectal cancer who underwent either local excision or conventional surgery after chemoradiotherapy. Methods: This was a retrospective multicentre study. Patients who underwent local excision were compared with those who had mesorectal excision. Quality of life and bowel function were investigated using validated questionnaires (European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-CR29 and Memorial Sloan-Kettering Cancer Center Bowel Function Instrument) at a median follow-up of 49 (range 13-95) months. Further analysis was undertaken of data from patients who underwent local excision alone compared with those requiring subsequent radical surgery. Statistical significance was set at P<0·010. Results: The mean constipation score was significantly better in the local excision group than in the mesorectal excision group (3·8 (95 per cent c.i. 0·3 to 7·2) versus 19·8 (12·1 to 27·4); P<0·001). Compared with patients who underwent mesorectal excision, those who had local excision had less sensation of incomplete emptying (mean score 3·7 (3·4 to 4·0) versus 2·8 (2·5 to 3·1); P<0·001) and second bowel movements within 15min (mean score 3·6 (3·3 to 3·9) versus 3·0 (2·7 to 3·3); P=0·006). Patients who underwent local excision alone scored better than those who had mesorectal excision, particularly for bowel function, who, in turn, scored better than patients requiring subsequent radical surgery following local excision. Conclusion: Patients who underwent local excision had a better quality of life and bowel function than those who underwent mesorectal excision.

Original languageEnglish
Pages (from-to)138-147
Number of pages10
JournalBritish Journal of Surgery
Volume104
Early online dateOct 5 2016
DOIs
Publication statusPublished - Jan 2017

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Chemoradiotherapy
Rectal Neoplasms
Quality of Life
Organizations
Neoplasms
Constipation
Research
Multicenter Studies
Retrospective Studies
Therapeutics

ASJC Scopus subject areas

  • Surgery

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Bowel function and quality of life after local excision or total mesorectal excision following chemoradiotherapy for rectal cancer. / Pucciarelli, Salvatore; Giandomenico, Francesca; De Paoli, Antonino; Gavaruzzi, Teresa; Lotto, Lorella; Mantello, Giovanna; Barba, C.; Zotti, Paola; Flora, S.; Del Bianco, Paola.

In: British Journal of Surgery, Vol. 104, 01.2017, p. 138-147.

Research output: Contribution to journalArticle

Pucciarelli, Salvatore ; Giandomenico, Francesca ; De Paoli, Antonino ; Gavaruzzi, Teresa ; Lotto, Lorella ; Mantello, Giovanna ; Barba, C. ; Zotti, Paola ; Flora, S. ; Del Bianco, Paola. / Bowel function and quality of life after local excision or total mesorectal excision following chemoradiotherapy for rectal cancer. In: British Journal of Surgery. 2017 ; Vol. 104. pp. 138-147.
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abstract = "Background: Local excision for rectal cancer is expected to offer a better functional outcome than conventional surgery. The aim of the present study was to compare quality of life and bowel function in patients with rectal cancer who underwent either local excision or conventional surgery after chemoradiotherapy. Methods: This was a retrospective multicentre study. Patients who underwent local excision were compared with those who had mesorectal excision. Quality of life and bowel function were investigated using validated questionnaires (European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-CR29 and Memorial Sloan-Kettering Cancer Center Bowel Function Instrument) at a median follow-up of 49 (range 13-95) months. Further analysis was undertaken of data from patients who underwent local excision alone compared with those requiring subsequent radical surgery. Statistical significance was set at P<0·010. Results: The mean constipation score was significantly better in the local excision group than in the mesorectal excision group (3·8 (95 per cent c.i. 0·3 to 7·2) versus 19·8 (12·1 to 27·4); P<0·001). Compared with patients who underwent mesorectal excision, those who had local excision had less sensation of incomplete emptying (mean score 3·7 (3·4 to 4·0) versus 2·8 (2·5 to 3·1); P<0·001) and second bowel movements within 15min (mean score 3·6 (3·3 to 3·9) versus 3·0 (2·7 to 3·3); P=0·006). Patients who underwent local excision alone scored better than those who had mesorectal excision, particularly for bowel function, who, in turn, scored better than patients requiring subsequent radical surgery following local excision. Conclusion: Patients who underwent local excision had a better quality of life and bowel function than those who underwent mesorectal excision.",
author = "Salvatore Pucciarelli and Francesca Giandomenico and {De Paoli}, Antonino and Teresa Gavaruzzi and Lorella Lotto and Giovanna Mantello and C. Barba and Paola Zotti and S. Flora and {Del Bianco}, Paola",
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T1 - Bowel function and quality of life after local excision or total mesorectal excision following chemoradiotherapy for rectal cancer

AU - Pucciarelli, Salvatore

AU - Giandomenico, Francesca

AU - De Paoli, Antonino

AU - Gavaruzzi, Teresa

AU - Lotto, Lorella

AU - Mantello, Giovanna

AU - Barba, C.

AU - Zotti, Paola

AU - Flora, S.

AU - Del Bianco, Paola

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Y1 - 2017/1

N2 - Background: Local excision for rectal cancer is expected to offer a better functional outcome than conventional surgery. The aim of the present study was to compare quality of life and bowel function in patients with rectal cancer who underwent either local excision or conventional surgery after chemoradiotherapy. Methods: This was a retrospective multicentre study. Patients who underwent local excision were compared with those who had mesorectal excision. Quality of life and bowel function were investigated using validated questionnaires (European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-CR29 and Memorial Sloan-Kettering Cancer Center Bowel Function Instrument) at a median follow-up of 49 (range 13-95) months. Further analysis was undertaken of data from patients who underwent local excision alone compared with those requiring subsequent radical surgery. Statistical significance was set at P<0·010. Results: The mean constipation score was significantly better in the local excision group than in the mesorectal excision group (3·8 (95 per cent c.i. 0·3 to 7·2) versus 19·8 (12·1 to 27·4); P<0·001). Compared with patients who underwent mesorectal excision, those who had local excision had less sensation of incomplete emptying (mean score 3·7 (3·4 to 4·0) versus 2·8 (2·5 to 3·1); P<0·001) and second bowel movements within 15min (mean score 3·6 (3·3 to 3·9) versus 3·0 (2·7 to 3·3); P=0·006). Patients who underwent local excision alone scored better than those who had mesorectal excision, particularly for bowel function, who, in turn, scored better than patients requiring subsequent radical surgery following local excision. Conclusion: Patients who underwent local excision had a better quality of life and bowel function than those who underwent mesorectal excision.

AB - Background: Local excision for rectal cancer is expected to offer a better functional outcome than conventional surgery. The aim of the present study was to compare quality of life and bowel function in patients with rectal cancer who underwent either local excision or conventional surgery after chemoradiotherapy. Methods: This was a retrospective multicentre study. Patients who underwent local excision were compared with those who had mesorectal excision. Quality of life and bowel function were investigated using validated questionnaires (European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-CR29 and Memorial Sloan-Kettering Cancer Center Bowel Function Instrument) at a median follow-up of 49 (range 13-95) months. Further analysis was undertaken of data from patients who underwent local excision alone compared with those requiring subsequent radical surgery. Statistical significance was set at P<0·010. Results: The mean constipation score was significantly better in the local excision group than in the mesorectal excision group (3·8 (95 per cent c.i. 0·3 to 7·2) versus 19·8 (12·1 to 27·4); P<0·001). Compared with patients who underwent mesorectal excision, those who had local excision had less sensation of incomplete emptying (mean score 3·7 (3·4 to 4·0) versus 2·8 (2·5 to 3·1); P<0·001) and second bowel movements within 15min (mean score 3·6 (3·3 to 3·9) versus 3·0 (2·7 to 3·3); P=0·006). Patients who underwent local excision alone scored better than those who had mesorectal excision, particularly for bowel function, who, in turn, scored better than patients requiring subsequent radical surgery following local excision. Conclusion: Patients who underwent local excision had a better quality of life and bowel function than those who underwent mesorectal excision.

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