TY - JOUR
T1 - Bowel parasitosis and neuroendocrine tumours of the appendix. A report from the Italian TREP project
AU - Virgone, C.
AU - Cecchetto, G.
AU - Besutti, V.
AU - Ferrari, A.
AU - Buffa, P.
AU - Alaggio, R.
AU - Alessandrini, L.
AU - Dall'Igna, P.
PY - 2015/5/6
Y1 - 2015/5/6
N2 - Five children with a neuroendocrine tumour (NET) of the appendix associated with a parasitic bowel infection are described, and the possibility of inflammation-triggered carcinogenesis is discussed. Schistosoma haematobium is linked primarily to bladder cancer but it has been reported in association with several other histotypes, including NETs of the gastrointestinal tract. Conversely, Enterobius vermicularis has not yet been claimed to participate in the onset of pre-cancerous conditions or tumours. The rare occurrence of contemporary appendiceal NETs and parasitic infection, raises the intriguing hypothesis of an inflammation-related carcinogenesis, although a cause-effect relationship cannot be established. Larger international series of childhood appendiceal NETs, which also include countries with higher prevalence of parasitic bowel infections, are needed to further clarify this possible cause-effect relationship.
AB - Five children with a neuroendocrine tumour (NET) of the appendix associated with a parasitic bowel infection are described, and the possibility of inflammation-triggered carcinogenesis is discussed. Schistosoma haematobium is linked primarily to bladder cancer but it has been reported in association with several other histotypes, including NETs of the gastrointestinal tract. Conversely, Enterobius vermicularis has not yet been claimed to participate in the onset of pre-cancerous conditions or tumours. The rare occurrence of contemporary appendiceal NETs and parasitic infection, raises the intriguing hypothesis of an inflammation-related carcinogenesis, although a cause-effect relationship cannot be established. Larger international series of childhood appendiceal NETs, which also include countries with higher prevalence of parasitic bowel infections, are needed to further clarify this possible cause-effect relationship.
KW - Carcinoid tumours of the appendix
KW - Enterobius vermicularis
KW - helminths
KW - neuroendocrine tumours
KW - Schistosoma hematobium
KW - TREP project
UR - http://www.scopus.com/inward/record.url?scp=84926421396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926421396&partnerID=8YFLogxK
U2 - 10.1017/S0950268814002404
DO - 10.1017/S0950268814002404
M3 - Article
C2 - 25216117
AN - SCOPUS:84926421396
VL - 143
SP - 1552
EP - 1555
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 7
ER -