Bowel parasitosis and neuroendocrine tumours of the appendix. A report from the Italian TREP project

C. Virgone, G. Cecchetto, V. Besutti, A. Ferrari, P. Buffa, R. Alaggio, L. Alessandrini, P. Dall'Igna

Research output: Contribution to journalArticlepeer-review


Five children with a neuroendocrine tumour (NET) of the appendix associated with a parasitic bowel infection are described, and the possibility of inflammation-triggered carcinogenesis is discussed. Schistosoma haematobium is linked primarily to bladder cancer but it has been reported in association with several other histotypes, including NETs of the gastrointestinal tract. Conversely, Enterobius vermicularis has not yet been claimed to participate in the onset of pre-cancerous conditions or tumours. The rare occurrence of contemporary appendiceal NETs and parasitic infection, raises the intriguing hypothesis of an inflammation-related carcinogenesis, although a cause-effect relationship cannot be established. Larger international series of childhood appendiceal NETs, which also include countries with higher prevalence of parasitic bowel infections, are needed to further clarify this possible cause-effect relationship.

Original languageEnglish
Pages (from-to)1552-1555
Number of pages4
JournalEpidemiology and Infection
Issue number7
Publication statusPublished - May 6 2015


  • Carcinoid tumours of the appendix
  • Enterobius vermicularis
  • helminths
  • neuroendocrine tumours
  • Schistosoma hematobium
  • TREP project

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology
  • Medicine(all)


Dive into the research topics of 'Bowel parasitosis and neuroendocrine tumours of the appendix. A report from the Italian TREP project'. Together they form a unique fingerprint.

Cite this