Bowel Sonoelastography in Patients with Crohn's Disease: A Systematic Review

L.C. Pescatori, G. Mauri, E. Savarino, L. Pastorelli, M. Vecchi, L.M. Sconfienza

Research output: Contribution to journalArticle

Abstract

Sonoelastography is an ultrasound-based method for evaluating the biological properties of a target tissue. It is commonly used in the diagnosis of liver and thyroid disease, but recently its use for monitoring the characteristics of bowel wall in patients affected by Crohn's disease (CD) has been proposed. Our aim was a systematic review of the use of sonoelastography in patients with CD. An initial database search retrieved 32 possible articles. On initial screening, 7 articles, concerning a total of 129 patients and 154 lesions of the small and large bowel, were finally included in the review. The age range varied between 6 and 53 y, and disease duration ranged between 1 and 623 mo. We collected data on the examinations performed (type and time), bowel area considered and parameters evaluated. All authors found that elastography correlates well with the degree of fibrosis, as wall strain significantly decreases in segments affected by fibrotic stenosis. Even though the endpoints proposed in the various articles are relatively inhomogeneous and scarcely comparable, we found that sonoelastography is a promising tool in the evaluation of patients with CD as it can differentiate inflammatory and fibrotic strictures in small case series. © 2018 World Federation for Ultrasound in Medicine and Biology
Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalUltrasound in Medicine and Biology
Volume44
Issue number2
DOIs
Publication statusPublished - 2018

Fingerprint

Elasticity Imaging Techniques
Crohn Disease
Pathologic Constriction
Thyroid Diseases
federations
fibrosis
Liver Diseases
Fibrosis
biology
medicine
liver
lesions
Medicine
Databases
screening
examination
evaluation

Keywords

  • Bowel stricture
  • Crohn's disease
  • Sonoelastography
  • Diseases
  • Medical imaging
  • Search engines
  • Biological properties
  • Database searches
  • Systematic Review
  • Target tissues
  • Thyroid disease
  • Diagnosis
  • age distribution
  • clinical evaluation
  • Crohn disease
  • diagnostic imaging
  • differential diagnosis
  • disease duration
  • disease severity
  • elastography
  • human
  • intestinal fibrosis
  • priority journal
  • Review
  • sonoelastography
  • systematic review
  • intestine
  • procedures
  • Crohn Disease
  • Elasticity Imaging Techniques
  • Humans
  • Intestines

Cite this

Bowel Sonoelastography in Patients with Crohn's Disease: A Systematic Review. / Pescatori, L.C.; Mauri, G.; Savarino, E.; Pastorelli, L.; Vecchi, M.; Sconfienza, L.M.

In: Ultrasound in Medicine and Biology, Vol. 44, No. 2, 2018, p. 297-302.

Research output: Contribution to journalArticle

Pescatori, L.C. ; Mauri, G. ; Savarino, E. ; Pastorelli, L. ; Vecchi, M. ; Sconfienza, L.M. / Bowel Sonoelastography in Patients with Crohn's Disease: A Systematic Review. In: Ultrasound in Medicine and Biology. 2018 ; Vol. 44, No. 2. pp. 297-302.
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title = "Bowel Sonoelastography in Patients with Crohn's Disease: A Systematic Review",
abstract = "Sonoelastography is an ultrasound-based method for evaluating the biological properties of a target tissue. It is commonly used in the diagnosis of liver and thyroid disease, but recently its use for monitoring the characteristics of bowel wall in patients affected by Crohn's disease (CD) has been proposed. Our aim was a systematic review of the use of sonoelastography in patients with CD. An initial database search retrieved 32 possible articles. On initial screening, 7 articles, concerning a total of 129 patients and 154 lesions of the small and large bowel, were finally included in the review. The age range varied between 6 and 53 y, and disease duration ranged between 1 and 623 mo. We collected data on the examinations performed (type and time), bowel area considered and parameters evaluated. All authors found that elastography correlates well with the degree of fibrosis, as wall strain significantly decreases in segments affected by fibrotic stenosis. Even though the endpoints proposed in the various articles are relatively inhomogeneous and scarcely comparable, we found that sonoelastography is a promising tool in the evaluation of patients with CD as it can differentiate inflammatory and fibrotic strictures in small case series. {\circledC} 2018 World Federation for Ultrasound in Medicine and Biology",
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author = "L.C. Pescatori and G. Mauri and E. Savarino and L. Pastorelli and M. Vecchi and L.M. Sconfienza",
note = "Cited By :5 Export Date: 5 February 2019 CODEN: USMBA Correspondence Address: Pescatori, L.C.; Scuola di Specializzazione in Radiodiagnostica, Universit{\`a} degli Studi di Milano, Via Festa del Perdono 7, 20123, Italy; email: lorenzo.carlo.pescatori@gmail.com References: Baumgart, D.C., M{\"u}ller, H.P., Grittner, U., Metzke, D., Fischer, A., Guckelberger, O., Pascher, A., Rudolph, B., US-based real-time elastography for the detection of fibrotic gut tissue in patients with stricturing crohn disease (2015) Radiology, 275, pp. 889-899; Baumgart, D.C., Sandborn, W.J., Crohn's disease (2012) Lancet, 380, pp. 1590-1605; Coelho, R., Ribeiro, H., Maconi, G., Bowel thickening in Crohn's disease: Fibrosis or inflammation? Diagnostic ultrasound imaging tools (2017) Inflamm Bowel Dis, 23, pp. 23-34; Cosgrove, D., Piscaglia, F., Bamber, J., Bojunga, J., Correas, J.-M., Gilja, O.H., Klauser, A.S., Dietrich, C.F., EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography: Part 2. Clinical applications (2013) Ultraschall Med, 34, pp. 238-253; Cosnes, J., Can we modulate the clinical course of inflammatory bowel diseases by our current treatment strategies? (2009) Dig Dis, 27, pp. 516-521; Dignass, A., Van Assche, G., Lindsay, J.O., L{\'e}mann, M., S{\"o}derholm, J., Colombel, J.F., Danese, S., Travis, S.P.L., The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management (2010) J Crohns Colitis, 4, pp. 28-62; Dillman, J.R., Stidham, R.W., Higgins, P.D.R., Moons, D.S., Johnson, L.A., Keshavarzi, N.R., Rubin, J.M., Ultrasound shear wave elastography helps discriminate low-grade from high-grade bowel wall fibrosis in ex vivo human intestinal specimens (2014) J Ultrasound Med, 33, pp. 2115-2123; Dillman, J.R., Stidham, R.W., Higgins, P.D.R., Moons, D.S., Johnson, L.A., Rubin, J.M., US elastography-derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in a Crohn disease animal model (2013) Radiology, 267, pp. 757-766; Fraquelli, M., Branchi, F., Cribi{\`u}, F.M., Orlando, S., Casazza, G., Magarotto, A., Massironi, S., Caprioli, F., The role of ultrasound elasticity imaging in predicting ileal fibrosis in Crohn's disease patients (2015) Inflamm Bowel Dis, 21, pp. 2605-2612; Fufezan, O., Asavoaie, C., Tamas, A., Farcau, D., Serban, D., Bowel elastography: A pilot study for developing an elastographic scoring system to evaluate disease activity in pediatric Crohn's disease (2015) Med Ultrason, 17, pp. 422-430; Havre, R., Leh, S., Gilja, O., {\O}degaard, S., Waage, J., Baatrup, G., Nesje, L., Strain assessment in surgically resected inflammatory and neoplastic bowel lesions (2012) Ultraschall Med, 35, pp. 149-158; Ishikawa, D., Ando, T., Watanabe, O., Ishiguro, K., Maeda, O., Miyake, N., Nakamura, M., Goto, H., Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis (2011) BMC Gastroenterol, 11, p. 29; Janssen, J., Schl{\"o}rer, E., Greiner, L., EUS elastography of the pancreas: Feasibility and pattern description of the normal pancreas, chronic pancreatitis, and focal pancreatic lesions (2007) Gastrointest Endosc, 65, pp. 971-978; Khoury, W., Strong, S.A., Fazio, V.W., Kiran, R.P., Factors associated with operative recurrence early after resection for Crohn's disease (2011) J Gastrointest Surg, 15, pp. 1354-1360; Lichtenstein, G.R., Olson, A., Travers, S., Diamond, R.H., Chen, D.M., Pritchard, M.L., Feagan, B.G., Sandborn, W.J., Factors associated with the development of intestinal strictures or obstructions in patients with Crohn's disease (2006) Am J Gastroenterol, 101, pp. 1030-1038; Loftus, C.G., Loftus, E., V, Harmsen, W.S., Zinsmeister, A.R., Tremaine, W.J., Melton, L.J., Sandborn, W.J., Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000 (2007) Inflamm Bowel Dis, 13, pp. 254-261; Maconi, G., Asthana, A.K., Bolzacchini, E., Dell'Era, A., Furfaro, F., Bezzio, C., Salvatore, V., Maier, J.A.M., Splanchnic hemodynamics and intestinal vascularity in Crohn's disease: An in vivo evaluation using Doppler and contrast-enhanced ultrasound and biochemical parameters (2016) Ultrasound Med Biol, 42, pp. 150-158; Sconfienza, L.M., Cavallaro, F., Colombi, V., Pastorelli, L., Tontini, G., Pescatori, L., Esseridou, A., Vecchi, M., In-vivo axial-strain sonoelastography helps distinguish acutely-inflamed from fibrotic terminal ileum strictures in patients with Crohn's disease: Preliminary results (2016) Ultrasound Med Biol, 42, pp. 855-863; Sconfienza, L.M., Orlandi, D., Cimmino, M.A., Silvestri, E., A few considerations on “Sonoelastography of the Plantar Fascia.” (2011) Radiology, 261, pp. 995-996; Sconfienza, L.M., Silvestri, E., Orlandi, D., Fabbro, E., Ferrero, G., Martini, C., Sardanelli, F., Cimmino, M.A., Real-time sonoelastography of the plantar fascia: Comparison between patients with plantar fasciitis and healthy control subjects (2013) Radiology, 267, pp. 195-200; Stidham, R.W., Xu, J., Johnson, L.A., Kim, K., Moons, D.S., McKenna, B.J., Rubin, J.M., Higgins, P.D.R., Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease (2011) Gastroenterology, 141, pp. 819-826. , e1; Van Assche, G., Vermeire, S., Rutgeerts, P., The potential for disease modification in Crohn's disease (2010) Nat Rev Gastroenterol Hepatol, 7, pp. 79-85",
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TY - JOUR

T1 - Bowel Sonoelastography in Patients with Crohn's Disease: A Systematic Review

AU - Pescatori, L.C.

AU - Mauri, G.

AU - Savarino, E.

AU - Pastorelli, L.

AU - Vecchi, M.

AU - Sconfienza, L.M.

N1 - Cited By :5 Export Date: 5 February 2019 CODEN: USMBA Correspondence Address: Pescatori, L.C.; Scuola di Specializzazione in Radiodiagnostica, Università degli Studi di Milano, Via Festa del Perdono 7, 20123, Italy; email: lorenzo.carlo.pescatori@gmail.com References: Baumgart, D.C., Müller, H.P., Grittner, U., Metzke, D., Fischer, A., Guckelberger, O., Pascher, A., Rudolph, B., US-based real-time elastography for the detection of fibrotic gut tissue in patients with stricturing crohn disease (2015) Radiology, 275, pp. 889-899; Baumgart, D.C., Sandborn, W.J., Crohn's disease (2012) Lancet, 380, pp. 1590-1605; Coelho, R., Ribeiro, H., Maconi, G., Bowel thickening in Crohn's disease: Fibrosis or inflammation? Diagnostic ultrasound imaging tools (2017) Inflamm Bowel Dis, 23, pp. 23-34; Cosgrove, D., Piscaglia, F., Bamber, J., Bojunga, J., Correas, J.-M., Gilja, O.H., Klauser, A.S., Dietrich, C.F., EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography: Part 2. Clinical applications (2013) Ultraschall Med, 34, pp. 238-253; Cosnes, J., Can we modulate the clinical course of inflammatory bowel diseases by our current treatment strategies? (2009) Dig Dis, 27, pp. 516-521; Dignass, A., Van Assche, G., Lindsay, J.O., Lémann, M., Söderholm, J., Colombel, J.F., Danese, S., Travis, S.P.L., The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management (2010) J Crohns Colitis, 4, pp. 28-62; Dillman, J.R., Stidham, R.W., Higgins, P.D.R., Moons, D.S., Johnson, L.A., Keshavarzi, N.R., Rubin, J.M., Ultrasound shear wave elastography helps discriminate low-grade from high-grade bowel wall fibrosis in ex vivo human intestinal specimens (2014) J Ultrasound Med, 33, pp. 2115-2123; Dillman, J.R., Stidham, R.W., Higgins, P.D.R., Moons, D.S., Johnson, L.A., Rubin, J.M., US elastography-derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in a Crohn disease animal model (2013) Radiology, 267, pp. 757-766; Fraquelli, M., Branchi, F., Cribiù, F.M., Orlando, S., Casazza, G., Magarotto, A., Massironi, S., Caprioli, F., The role of ultrasound elasticity imaging in predicting ileal fibrosis in Crohn's disease patients (2015) Inflamm Bowel Dis, 21, pp. 2605-2612; Fufezan, O., Asavoaie, C., Tamas, A., Farcau, D., Serban, D., Bowel elastography: A pilot study for developing an elastographic scoring system to evaluate disease activity in pediatric Crohn's disease (2015) Med Ultrason, 17, pp. 422-430; Havre, R., Leh, S., Gilja, O., Ødegaard, S., Waage, J., Baatrup, G., Nesje, L., Strain assessment in surgically resected inflammatory and neoplastic bowel lesions (2012) Ultraschall Med, 35, pp. 149-158; Ishikawa, D., Ando, T., Watanabe, O., Ishiguro, K., Maeda, O., Miyake, N., Nakamura, M., Goto, H., Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis (2011) BMC Gastroenterol, 11, p. 29; Janssen, J., Schlörer, E., Greiner, L., EUS elastography of the pancreas: Feasibility and pattern description of the normal pancreas, chronic pancreatitis, and focal pancreatic lesions (2007) Gastrointest Endosc, 65, pp. 971-978; Khoury, W., Strong, S.A., Fazio, V.W., Kiran, R.P., Factors associated with operative recurrence early after resection for Crohn's disease (2011) J Gastrointest Surg, 15, pp. 1354-1360; Lichtenstein, G.R., Olson, A., Travers, S., Diamond, R.H., Chen, D.M., Pritchard, M.L., Feagan, B.G., Sandborn, W.J., Factors associated with the development of intestinal strictures or obstructions in patients with Crohn's disease (2006) Am J Gastroenterol, 101, pp. 1030-1038; Loftus, C.G., Loftus, E., V, Harmsen, W.S., Zinsmeister, A.R., Tremaine, W.J., Melton, L.J., Sandborn, W.J., Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000 (2007) Inflamm Bowel Dis, 13, pp. 254-261; Maconi, G., Asthana, A.K., Bolzacchini, E., Dell'Era, A., Furfaro, F., Bezzio, C., Salvatore, V., Maier, J.A.M., Splanchnic hemodynamics and intestinal vascularity in Crohn's disease: An in vivo evaluation using Doppler and contrast-enhanced ultrasound and biochemical parameters (2016) Ultrasound Med Biol, 42, pp. 150-158; Sconfienza, L.M., Cavallaro, F., Colombi, V., Pastorelli, L., Tontini, G., Pescatori, L., Esseridou, A., Vecchi, M., In-vivo axial-strain sonoelastography helps distinguish acutely-inflamed from fibrotic terminal ileum strictures in patients with Crohn's disease: Preliminary results (2016) Ultrasound Med Biol, 42, pp. 855-863; Sconfienza, L.M., Orlandi, D., Cimmino, M.A., Silvestri, E., A few considerations on “Sonoelastography of the Plantar Fascia.” (2011) Radiology, 261, pp. 995-996; Sconfienza, L.M., Silvestri, E., Orlandi, D., Fabbro, E., Ferrero, G., Martini, C., Sardanelli, F., Cimmino, M.A., Real-time sonoelastography of the plantar fascia: Comparison between patients with plantar fasciitis and healthy control subjects (2013) Radiology, 267, pp. 195-200; Stidham, R.W., Xu, J., Johnson, L.A., Kim, K., Moons, D.S., McKenna, B.J., Rubin, J.M., Higgins, P.D.R., Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease (2011) Gastroenterology, 141, pp. 819-826. , e1; Van Assche, G., Vermeire, S., Rutgeerts, P., The potential for disease modification in Crohn's disease (2010) Nat Rev Gastroenterol Hepatol, 7, pp. 79-85

PY - 2018

Y1 - 2018

N2 - Sonoelastography is an ultrasound-based method for evaluating the biological properties of a target tissue. It is commonly used in the diagnosis of liver and thyroid disease, but recently its use for monitoring the characteristics of bowel wall in patients affected by Crohn's disease (CD) has been proposed. Our aim was a systematic review of the use of sonoelastography in patients with CD. An initial database search retrieved 32 possible articles. On initial screening, 7 articles, concerning a total of 129 patients and 154 lesions of the small and large bowel, were finally included in the review. The age range varied between 6 and 53 y, and disease duration ranged between 1 and 623 mo. We collected data on the examinations performed (type and time), bowel area considered and parameters evaluated. All authors found that elastography correlates well with the degree of fibrosis, as wall strain significantly decreases in segments affected by fibrotic stenosis. Even though the endpoints proposed in the various articles are relatively inhomogeneous and scarcely comparable, we found that sonoelastography is a promising tool in the evaluation of patients with CD as it can differentiate inflammatory and fibrotic strictures in small case series. © 2018 World Federation for Ultrasound in Medicine and Biology

AB - Sonoelastography is an ultrasound-based method for evaluating the biological properties of a target tissue. It is commonly used in the diagnosis of liver and thyroid disease, but recently its use for monitoring the characteristics of bowel wall in patients affected by Crohn's disease (CD) has been proposed. Our aim was a systematic review of the use of sonoelastography in patients with CD. An initial database search retrieved 32 possible articles. On initial screening, 7 articles, concerning a total of 129 patients and 154 lesions of the small and large bowel, were finally included in the review. The age range varied between 6 and 53 y, and disease duration ranged between 1 and 623 mo. We collected data on the examinations performed (type and time), bowel area considered and parameters evaluated. All authors found that elastography correlates well with the degree of fibrosis, as wall strain significantly decreases in segments affected by fibrotic stenosis. Even though the endpoints proposed in the various articles are relatively inhomogeneous and scarcely comparable, we found that sonoelastography is a promising tool in the evaluation of patients with CD as it can differentiate inflammatory and fibrotic strictures in small case series. © 2018 World Federation for Ultrasound in Medicine and Biology

KW - Bowel stricture

KW - Crohn's disease

KW - Sonoelastography

KW - Diseases

KW - Medical imaging

KW - Search engines

KW - Biological properties

KW - Database searches

KW - Systematic Review

KW - Target tissues

KW - Thyroid disease

KW - Diagnosis

KW - age distribution

KW - clinical evaluation

KW - Crohn disease

KW - diagnostic imaging

KW - differential diagnosis

KW - disease duration

KW - disease severity

KW - elastography

KW - human

KW - intestinal fibrosis

KW - priority journal

KW - Review

KW - sonoelastography

KW - systematic review

KW - intestine

KW - procedures

KW - Crohn Disease

KW - Elasticity Imaging Techniques

KW - Humans

KW - Intestines

U2 - 10.1016/j.ultrasmedbio.2017.10.004

DO - 10.1016/j.ultrasmedbio.2017.10.004

M3 - Article

VL - 44

SP - 297

EP - 302

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 2

ER -