Bowel ultrasound imaging in patients with cystic fibrosis

Relationship with clinical symptoms and CFTR genotype

Mirella Fraquelli, Alessandra Baccarin, Fabiola Corti, Clara Benedetta Conti, Maria Chiara Russo, Serena Della Valle, Roberta Pozzi, Massimo Cressoni, Dario Conte, Carla Colombo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Ultrasound imaging is used to assess bowel abnormalities in gastrointestinal diseases. We aimed to assess the rate of predefined bowel ultrasound signs and their relationship with gastrointestinal symptoms and the cystic fibrosis transmembrane conductance regulator (CFTR) genotype in cystic fibrosis patients in regular follow-up. Methods: Prospective study of 70 consecutive patients with cystic fibrosis and 45 controls who underwent abdominal ultrasound; pertinent findings were related to gastrointestinal symptoms and, in cystic fibrosis patients, to pancreatic status, malabsorption degree, lipase intake, CFTR genotype (classified as severe or mild against functional class of CFTR mutations). Results: 96% patients showed at least one abnormal bowel ultrasound sign. Most frequent signs were lymph node enlargement (64%), bowel loop dilatation (55%), thick corpuscular intraluminal content (49%), bowel wall hypervascularization (26%), thickened bowel wall (22%) and intussusception (17%). Patients with recurrent abdominal pain showed more bowel wall hypervascularization than patients without recurrent pain (47% vs. 19%, respectively; p = 0.02) and intussusception (58% vs. 17%, respectively; p <0.01). Genotype was not associated to specific bowel ultrasound signs. Patients with bowel loop intussusception showed greater lipase intake than those without intussusception (8.118 ± 2.083 vs. 5.994 ± 4.187, respectively; p <0.01). Conclusion: Cystic fibrosis patients present a higher rate of bowel ultrasound abnormalities than controls. Bowel ultrasound abnormalities are associated with abdominal symptoms.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalDigestive and Liver Disease
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Cystic Fibrosis Transmembrane Conductance Regulator
Cystic Fibrosis
Ultrasonography
Genotype
Intussusception
Lipase
Gastrointestinal Diseases
Abdominal Pain
Dilatation
Lymph Nodes
Prospective Studies
Pain
Mutation

Keywords

  • Abdominal symptoms
  • Bowel ultrasound
  • Cystic fibrosis
  • Intussusception

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Bowel ultrasound imaging in patients with cystic fibrosis : Relationship with clinical symptoms and CFTR genotype. / Fraquelli, Mirella; Baccarin, Alessandra; Corti, Fabiola; Conti, Clara Benedetta; Russo, Maria Chiara; Valle, Serena Della; Pozzi, Roberta; Cressoni, Massimo; Conte, Dario; Colombo, Carla.

In: Digestive and Liver Disease, Vol. 48, No. 3, 01.03.2016, p. 271-276.

Research output: Contribution to journalArticle

Fraquelli, Mirella ; Baccarin, Alessandra ; Corti, Fabiola ; Conti, Clara Benedetta ; Russo, Maria Chiara ; Valle, Serena Della ; Pozzi, Roberta ; Cressoni, Massimo ; Conte, Dario ; Colombo, Carla. / Bowel ultrasound imaging in patients with cystic fibrosis : Relationship with clinical symptoms and CFTR genotype. In: Digestive and Liver Disease. 2016 ; Vol. 48, No. 3. pp. 271-276.
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AB - Background: Ultrasound imaging is used to assess bowel abnormalities in gastrointestinal diseases. We aimed to assess the rate of predefined bowel ultrasound signs and their relationship with gastrointestinal symptoms and the cystic fibrosis transmembrane conductance regulator (CFTR) genotype in cystic fibrosis patients in regular follow-up. Methods: Prospective study of 70 consecutive patients with cystic fibrosis and 45 controls who underwent abdominal ultrasound; pertinent findings were related to gastrointestinal symptoms and, in cystic fibrosis patients, to pancreatic status, malabsorption degree, lipase intake, CFTR genotype (classified as severe or mild against functional class of CFTR mutations). Results: 96% patients showed at least one abnormal bowel ultrasound sign. Most frequent signs were lymph node enlargement (64%), bowel loop dilatation (55%), thick corpuscular intraluminal content (49%), bowel wall hypervascularization (26%), thickened bowel wall (22%) and intussusception (17%). Patients with recurrent abdominal pain showed more bowel wall hypervascularization than patients without recurrent pain (47% vs. 19%, respectively; p = 0.02) and intussusception (58% vs. 17%, respectively; p <0.01). Genotype was not associated to specific bowel ultrasound signs. Patients with bowel loop intussusception showed greater lipase intake than those without intussusception (8.118 ± 2.083 vs. 5.994 ± 4.187, respectively; p <0.01). Conclusion: Cystic fibrosis patients present a higher rate of bowel ultrasound abnormalities than controls. Bowel ultrasound abnormalities are associated with abdominal symptoms.

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