Brachial and central blood pressure in HIV-infected subjects

Alessandro Maloberti, Dario Dozio, Mauro Betelli, Alessandra Bandera, Nicola Squillace, Andrea Gori, Giovanna Castoldi, Andrea Stella, Giuseppe Mancia, Cristina Giannattasio

Research output: Contribution to journalArticlepeer-review

Abstract

HIV infected subjects present an unfavorable cardiovascular (CV) risk profile that is determined by the infection itself, highly active anti-retroviral therapy (HAART) and other factors, such as chronic kidney disease (CKD). Information is scant and contradictory on whether these factors are associated with arterial stiffness and blood pressure (BP) alteration. Our study aimed to evaluate those parameters in HIV-positive subjects both with and without HAART and with and without CKD, which was defined as the presence of microalbuminuria with a normal glomerular filtration rate. We enrolled 94 HIV-infected subjects without known CV risk factors and compared them with 37 control subjects. We recorded brachial and central BP (pulse wave analysis) and pulse wave velocity (SphygmoCor). HIV-positive subjects of similar ages and with similar BP values showed central pulse pressure values that were significantly greater than those of controls; this was also the case for the Aix value. Central systolic and pulse pressure values and Aix were significantly greater in HIV-positive subjects with HAART and CKD than in the other HIV-positive subgroups and control subjects. PWV was also superimposable between groups when the data were analyzed relative to the presence of HAART and CKD. Our study shows that the unfavorable CV risk profile associated with HIV infection includes an increase in both central BP and Aix. The central BP increase seems to be favored by renal damage, which apparently has a role in the early stages of the disease.

Original languageEnglish
Pages (from-to)405-412
Number of pages8
JournalHypertension Research
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 8 2015

Keywords

  • arterial stiffness
  • central blood pressure
  • highly active anti-retroviral therapy
  • HIV infection
  • pulse wave analysis
  • pulse wave velocity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Brachial and central blood pressure in HIV-infected subjects'. Together they form a unique fingerprint.

Cite this