TY - JOUR
T1 - Brachial and central blood pressure in HIV-infected subjects
AU - Maloberti, Alessandro
AU - Dozio, Dario
AU - Betelli, Mauro
AU - Bandera, Alessandra
AU - Squillace, Nicola
AU - Gori, Andrea
AU - Castoldi, Giovanna
AU - Stella, Andrea
AU - Mancia, Giuseppe
AU - Giannattasio, Cristina
PY - 2015/6/8
Y1 - 2015/6/8
N2 - HIV infected subjects present an unfavorable cardiovascular (CV) risk profile that is determined by the infection itself, highly active anti-retroviral therapy (HAART) and other factors, such as chronic kidney disease (CKD). Information is scant and contradictory on whether these factors are associated with arterial stiffness and blood pressure (BP) alteration. Our study aimed to evaluate those parameters in HIV-positive subjects both with and without HAART and with and without CKD, which was defined as the presence of microalbuminuria with a normal glomerular filtration rate. We enrolled 94 HIV-infected subjects without known CV risk factors and compared them with 37 control subjects. We recorded brachial and central BP (pulse wave analysis) and pulse wave velocity (SphygmoCor). HIV-positive subjects of similar ages and with similar BP values showed central pulse pressure values that were significantly greater than those of controls; this was also the case for the Aix value. Central systolic and pulse pressure values and Aix were significantly greater in HIV-positive subjects with HAART and CKD than in the other HIV-positive subgroups and control subjects. PWV was also superimposable between groups when the data were analyzed relative to the presence of HAART and CKD. Our study shows that the unfavorable CV risk profile associated with HIV infection includes an increase in both central BP and Aix. The central BP increase seems to be favored by renal damage, which apparently has a role in the early stages of the disease.
AB - HIV infected subjects present an unfavorable cardiovascular (CV) risk profile that is determined by the infection itself, highly active anti-retroviral therapy (HAART) and other factors, such as chronic kidney disease (CKD). Information is scant and contradictory on whether these factors are associated with arterial stiffness and blood pressure (BP) alteration. Our study aimed to evaluate those parameters in HIV-positive subjects both with and without HAART and with and without CKD, which was defined as the presence of microalbuminuria with a normal glomerular filtration rate. We enrolled 94 HIV-infected subjects without known CV risk factors and compared them with 37 control subjects. We recorded brachial and central BP (pulse wave analysis) and pulse wave velocity (SphygmoCor). HIV-positive subjects of similar ages and with similar BP values showed central pulse pressure values that were significantly greater than those of controls; this was also the case for the Aix value. Central systolic and pulse pressure values and Aix were significantly greater in HIV-positive subjects with HAART and CKD than in the other HIV-positive subgroups and control subjects. PWV was also superimposable between groups when the data were analyzed relative to the presence of HAART and CKD. Our study shows that the unfavorable CV risk profile associated with HIV infection includes an increase in both central BP and Aix. The central BP increase seems to be favored by renal damage, which apparently has a role in the early stages of the disease.
KW - arterial stiffness
KW - central blood pressure
KW - highly active anti-retroviral therapy
KW - HIV infection
KW - pulse wave analysis
KW - pulse wave velocity
UR - http://www.scopus.com/inward/record.url?scp=84930520623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930520623&partnerID=8YFLogxK
U2 - 10.1038/hr.2015.25
DO - 10.1038/hr.2015.25
M3 - Article
C2 - 25740293
AN - SCOPUS:84930520623
VL - 38
SP - 405
EP - 412
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 6
ER -