BrachyView, a novel in-body imaging system for HDR prostate brachytherapy: Experimental evaluation

M. Safavi-Naeini, Z. Han, S. Alnaghy, D. Cutajar, M. Petasecca, M. L F Lerch, D. R. Franklin, J. Bucci, M. Carrara, M. Zaider, A. B. Rosenfeld

Research output: Contribution to journalArticle

Abstract

Purpose: This paper presents initial experimental results from a prototype of high dose rate (HDR) BrachyView, a novel in-body source tracking system for HDR brachytherapy based on a multipinhole tungsten collimator and a high resolution pixellated silicon detector array. The probe and its associated position estimation algorithms are validated and a comprehensive evaluation of the accuracy of its position estimation capabilities is presented. Methods: The HDR brachytherapy source is moved through a sequence of positions in a prostate phantom, for various displacements in x, y, and z. For each position, multiple image acquisitions are performed, and source positions are reconstructed. Error estimates in each dimension are calculated at each source position and combined to calculate overall positioning errors. Gafchromic film is used to validate the accuracy of source placement within the phantom. Results: More than 90% of evaluated source positions were estimated with an error of less than one millimeter, with the worst-case error being 1.3 mm. Experimental results were in close agreement with previously published Monte Carlo simulation results. Conclusions: The prototype of HDR BrachyView demonstrates a satisfactory level of accuracy in its source position estimation, and additional improvements are achievable with further refinement of HDR BrachyView's image processing algorithms.

Original languageEnglish
Pages (from-to)7098-7107
Number of pages10
JournalMedical Physics
Volume42
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • brachytherapy
  • BrachyView
  • HDR
  • in vivo dosimetry

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'BrachyView, a novel in-body imaging system for HDR prostate brachytherapy: Experimental evaluation'. Together they form a unique fingerprint.

  • Cite this

    Safavi-Naeini, M., Han, Z., Alnaghy, S., Cutajar, D., Petasecca, M., Lerch, M. L. F., Franklin, D. R., Bucci, J., Carrara, M., Zaider, M., & Rosenfeld, A. B. (2015). BrachyView, a novel in-body imaging system for HDR prostate brachytherapy: Experimental evaluation. Medical Physics, 42(12), 7098-7107. https://doi.org/10.1118/1.4935866