BrachyView: Multiple seed position reconstruction and comparison with CT post-implant dosimetry

S. Alnaghy, K. J. Loo, D. L. Cutajar, M. Jalayer, C. Tenconi, M. Favoino, R. Rietti, M. Tartaglia, F. Carriero, M. Safavi-Naeini, J. Bucci, J. Jakubek, S. Pospisil, M. Zaider, M. L F Lerch, A. B. Rosenfeld, Marco Petasecca

Research output: Contribution to journalArticlepeer-review

Abstract

BrachyView is a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and a pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options for real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In a previous proof-of-concept study, the justification of the pinhole concept was shown, allowing for the next step whereby multiple active seeds are implanted into a PMMA phantom to simulate a more realistic clinical scenario. In this study, 20 seeds were implanted and imaged using a lead pinhole of 400 μ m diameter. BrachyView was able to resolve the seed positions within 1-2 mm of expected positions, which was verified by co-registering with a full clinical post-implant CT scan.

Original languageEnglish
Article numberP05002
JournalJournal of Instrumentation
Volume11
Issue number5
DOIs
Publication statusPublished - May 3 2016

Keywords

  • Dosimetry concepts and apparatus
  • Instrumentation for gammaelectron therapy
  • Intra-operative probes
  • X-ray detectors

ASJC Scopus subject areas

  • Instrumentation
  • Mathematical Physics

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