Bradykinin b2-receptor blockade facilitates deoxycorticosterone-salt hypertension

Paolo Madeddu; Paolo Pinna Parpaglia; Maria Piera Demontis; Maria Vittoria Varoni; Maria Caterina Fattaccio; Giancarlo Tonolo; Chiara Troffa; Nicola Glorioso

Bradykinin b₂-receptor blockade facilitates deoxycorticosterone-salt hypertension

Paolo Madeddu, Paolo Pinna Parpaglia, Maria Piera Demontis, Maria Vittoria Varoni, Maria Caterina Fattaccio, Giancarlo Tonolo, Chiara Troffa, Nicola Glorioso

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

The contribution of endogenous kinins to the regulation of blood pressure, urinary volume, and renal sodium excretion was evaluated in Wistar rats on higb sodium intake by using the new bradykinin receptor antagonist Hoe 140 (D-Arg,[Hyp’, Thi^s, D-Tic⁷, Oic']-bradykinin). Neither Hoe 140 (3 nmol/hr s.c. for 4 weeks) nor its vehicle altered systolic blood pressure (tail-cuff plethysmography) or renal (Unction in rats given saline solution (0.15 mol/L NaCI) to drink ad libitum. Four-week administration of deoxycorticosterone (DOC), combined with high sodium intake and uninephrectomy, increased systolic blood pressure from 127±3 to 160±3 mm Hg (p

Original language	English
Pages (from-to)	980-984
Number of pages	5
Journal	Hypertension
Volume	21
Issue number	6
Publication status	Published - 1993

Keywords

Blood pressure
Bradykinin
Kallikrein
Kinins
Mineralocorticoids

ASJC Scopus subject areas

Internal Medicine

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Bradykinin b₂-receptor blockade facilitates deoxycorticosterone-salt hypertension. / Madeddu, Paolo; Parpaglia, Paolo Pinna; Demontis, Maria Piera; Varoni, Maria Vittoria; Fattaccio, Maria Caterina; Tonolo, Giancarlo; Troffa, Chiara; Glorioso, Nicola.

In: Hypertension, Vol. 21, No. 6, 1993, p. 980-984.

Research output: Contribution to journal › Article › peer-review

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AU - Tonolo, Giancarlo

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