TY - JOUR
T1 - Bradykinin b2-receptor blockade facilitates deoxycorticosterone-salt hypertension
AU - Madeddu, Paolo
AU - Parpaglia, Paolo Pinna
AU - Demontis, Maria Piera
AU - Varoni, Maria Vittoria
AU - Fattaccio, Maria Caterina
AU - Tonolo, Giancarlo
AU - Troffa, Chiara
AU - Glorioso, Nicola
PY - 1993
Y1 - 1993
N2 - The contribution of endogenous kinins to the regulation of blood pressure, urinary volume, and renal sodium excretion was evaluated in Wistar rats on higb sodium intake by using the new bradykinin receptor antagonist Hoe 140 (D-Arg,[Hyp’, This, D-Tic7, Oic']-bradykinin). Neither Hoe 140 (3 nmol/hr s.c. for 4 weeks) nor its vehicle altered systolic blood pressure (tail-cuff plethysmography) or renal (Unction in rats given saline solution (0.15 mol/L NaCI) to drink ad libitum. Four-week administration of deoxycorticosterone (DOC), combined with high sodium intake and uninephrectomy, increased systolic blood pressure from 127±3 to 160±3 mm Hg (p
AB - The contribution of endogenous kinins to the regulation of blood pressure, urinary volume, and renal sodium excretion was evaluated in Wistar rats on higb sodium intake by using the new bradykinin receptor antagonist Hoe 140 (D-Arg,[Hyp’, This, D-Tic7, Oic']-bradykinin). Neither Hoe 140 (3 nmol/hr s.c. for 4 weeks) nor its vehicle altered systolic blood pressure (tail-cuff plethysmography) or renal (Unction in rats given saline solution (0.15 mol/L NaCI) to drink ad libitum. Four-week administration of deoxycorticosterone (DOC), combined with high sodium intake and uninephrectomy, increased systolic blood pressure from 127±3 to 160±3 mm Hg (p
KW - Blood pressure
KW - Bradykinin
KW - Kallikrein
KW - Kinins
KW - Mineralocorticoids
UR - http://www.scopus.com/inward/record.url?scp=0027190647&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027190647&partnerID=8YFLogxK
M3 - Article
C2 - 8389326
AN - SCOPUS:0027190647
VL - 21
SP - 980
EP - 984
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 6
ER -