BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis

C. Cremolini; M. Di Bartolomeo; A. Amatu; C. Antoniotti; R. Moretto; R. Berenato; F. Perrone; E. Tamborini; G. Aprile; S. Lonardi; A. Sartore-Bianchi; G. Fontanini; M. Milione; C. Lauricella; S. Siena; A. Falcone; F. De Braud; F. Loupakis; Filippo Pietrantonio

doi:10.1093/annonc/mdv290

BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis

C. Cremolini, M. Di Bartolomeo, A. Amatu, C. Antoniotti, R. Moretto, R. Berenato, F. Perrone, E. Tamborini, G. Aprile, S. Lonardi, A. Sartore-Bianchi, G. Fontanini, M. Milione, C. Lauricella, S. Siena, A. Falcone, F. De Braud, F. Loupakis, Filippo Pietrantonio

Research output: Contribution to journal › Article

Abstract

Background: While the negative prognostic role of BRAF V600E mutation in metastatic colorectal cancer (mCRC) is well established, the impact of BRAF codons 594 and 596 mutations, occurring in

Original language	English
Article number	mdv290
Pages (from-to)	2092-2097
Number of pages	6
Journal	Annals of Oncology
Volume	26
Issue number	10
DOIs	https://doi.org/10.1093/annonc/mdv290
Publication status	Published - Oct 1 2015

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Keywords

BRAF
Codons 594 and 596
Colorectal cancer
Prognosis

ASJC Scopus subject areas

Oncology
Hematology

Cite this

Cremolini, C., Di Bartolomeo, M., Amatu, A., Antoniotti, C., Moretto, R., Berenato, R., Perrone, F., Tamborini, E., Aprile, G., Lonardi, S., Sartore-Bianchi, A., Fontanini, G., Milione, M., Lauricella, C., Siena, S., Falcone, A., De Braud, F., Loupakis, F., & Pietrantonio, F. (2015). BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis. Annals of Oncology, 26(10), 2092-2097. [mdv290]. https://doi.org/10.1093/annonc/mdv290

BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis. / Cremolini, C.; Di Bartolomeo, M.; Amatu, A.; Antoniotti, C.; Moretto, R.; Berenato, R.; Perrone, F.; Tamborini, E.; Aprile, G.; Lonardi, S.; Sartore-Bianchi, A.; Fontanini, G.; Milione, M.; Lauricella, C.; Siena, S.; Falcone, A.; De Braud, F.; Loupakis, F.; Pietrantonio, Filippo.

In: Annals of Oncology, Vol. 26, No. 10, mdv290, 01.10.2015, p. 2092-2097.

Research output: Contribution to journal › Article

Cremolini, C, Di Bartolomeo, M, Amatu, A, Antoniotti, C, Moretto, R, Berenato, R, Perrone, F , Tamborini, E, Aprile, G, Lonardi, S, Sartore-Bianchi, A, Fontanini, G, Milione, M, Lauricella, C, Siena, S, Falcone, A, De Braud, F, Loupakis, F & Pietrantonio, F 2015, 'BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis', Annals of Oncology, vol. 26, no. 10, mdv290, pp. 2092-2097. https://doi.org/10.1093/annonc/mdv290

Cremolini, C. ; Di Bartolomeo, M. ; Amatu, A. ; Antoniotti, C. ; Moretto, R. ; Berenato, R. ; Perrone, F. ; Tamborini, E. ; Aprile, G. ; Lonardi, S. ; Sartore-Bianchi, A. ; Fontanini, G. ; Milione, M. ; Lauricella, C. ; Siena, S. ; Falcone, A. ; De Braud, F. ; Loupakis, F. ; Pietrantonio, Filippo. / BRAF codons 594 and 596 mutations identify a new molecular subtype of metastatic colorectal cancer at favorable prognosis. In: Annals of Oncology. 2015 ; Vol. 26, No. 10. pp. 2092-2097.

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10.1093/annonc/mdv290