BRAF mutations are not a major event in post-chernobyl childhood thyroid carcinomas

Jorge Lima, Vítor Trovisco, Paula Soares, Valdemar Máximo, João Magalhães, Giuliana Salvatore, Massimo Santoro, Tatyana Bogdanova, Mykola Tronko, Alexander Abrosimov, Steve Jeremiah, Gerry Thomas, Dillwyn Williams, Manuel Sobrinho-Simões

Research output: Contribution to journalArticle

Abstract

The BRAF gene has been shown to be a major target for mutations in papillary thyroid carcinoma (PTC) (36-69%), which forms almost all of the over 2000 cases of thyroid carcinoma that have occurred in Chernobyl. BRAF is activated by point mutation, and were it to occur at a high frequency in Chernobyl-related tumors, it would challenge the dominant role of double-strand breaks in radiation-induced PTC. In a previous study, we detected the BRAF V600E mutation in 46% (23 of 50) of sporadic adult PTC. Using the same methodology, we have analyzed 34 post-Chernobyl PTC and detected RET/PTC re-arrangements in 14 (41%) and BRAF mutations (V600E) in four (12%). These two alterations did not coexist in any PTCs. The mean age at exposure of patients with PTC showing BRAF mutation was higher than that of patients with tumors without BRAF mutation irrespective of their RET status. We have also analyzed 17 sporadic cases of childhood PTC and found that only one (6%) harbored the BAAF V600E mutation. We conclude that the frequency of BRAF mutations is significantly lower (P = 0.0008) in post-Chernobyl PTC than in adult sporadic PTC, whereas no significant difference was found between post-Chernobyl and sporadic childhood PTCs.

Original languageEnglish
Pages (from-to)4267-4271
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number9
DOIs
Publication statusPublished - Sep 2004

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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    Lima, J., Trovisco, V., Soares, P., Máximo, V., Magalhães, J., Salvatore, G., Santoro, M., Bogdanova, T., Tronko, M., Abrosimov, A., Jeremiah, S., Thomas, G., Williams, D., & Sobrinho-Simões, M. (2004). BRAF mutations are not a major event in post-chernobyl childhood thyroid carcinomas. Journal of Clinical Endocrinology and Metabolism, 89(9), 4267-4271. https://doi.org/10.1210/jc.2003-032224