BRAF V600E and risk stratification of thyroid microcarcinoma: A multicenter pathological and clinical study

Giovanni Tallini, Dario De Biase, Cosimo Durante, Giorgia Acquaviva, Michele Bisceglia, Rocco Bruno, Maria Letizia Bacchi Reggiani, Gian Piero Casadei, Giuseppe Costante, Nadia Cremonini, Livia Lamartina, Domenico Meringolo, Francesco Nardi, Annalisa Pession, Kerry J. Rhoden, Giuseppe Ronga, Massimo Torlontano, Antonella Verrienti, Michela Visani, Sebastiano Filetti

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Studies from single institutions have analyzed BRAF in papillary microcarcinomas, sometimes with contradictory results. Most of them have provided limited integration of histological and clinical data. To obtain a comprehensive picture of BRAF V600E-mutated microcarcinomas and to evaluate the role of BRAF testing in risk stratification we performed a retrospective multicenter analysis integrating microscopical, pathological, and clinical information. Three hundred and sixty-five samples from 300 patients treated at six medical institutions covering different geographical regions of Italy were analyzed with central review of all cases. BRAF V600E statistical analysis was conducted on 298 microcarcinomas from 264 patients after exclusion of those that did not meet the required criteria. BRAF V600E was identified in 145/298 tumors (49%) including the following subtypes: 35/37 (95%, P

Original languageEnglish
Pages (from-to)1343-1359
Number of pages17
JournalModern Pathology
Issue number10
Publication statusPublished - Oct 3 2015


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tallini, G., De Biase, D., Durante, C., Acquaviva, G., Bisceglia, M., Bruno, R., Bacchi Reggiani, M. L., Casadei, G. P., Costante, G., Cremonini, N., Lamartina, L., Meringolo, D., Nardi, F., Pession, A., Rhoden, K. J., Ronga, G., Torlontano, M., Verrienti, A., Visani, M., & Filetti, S. (2015). BRAF V600E and risk stratification of thyroid microcarcinoma: A multicenter pathological and clinical study. Modern Pathology, 28(10), 1343-1359.