Brain β-endorphin concentrations in experimental chronic liver disease

A. E. Panerai, F. Salerno, F. Baldissera, A. Martini, A. M. Di Giulio, P. Mantegazza

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

β-Endorphin, Met-enkephalin, substance P and somatostatin concentrations have been evaluated in brain areas of rats with severe liver disease obtained by chronic pretreatment with CCl4 for 3 or 9 weeks. β-Endorphin, but not Met-enkephalin, somatostatin or substance P concentrations were significantly decreased in the hypothalamus of both the three and nine week-treatment groups. The β-endorphin decrease we observed might be tentatively attributed to a modification of GABA levels, but not serotonin, since the stimulation of the serotoninergic system induced a significant increase, while the potentiation of the GABAergic system induced a clear decrease of β-endorphin concentrations in the hypothalamus of treated rats.

Original languageEnglish
Pages (from-to)188-190
Number of pages3
JournalBrain Research
Volume247
Issue number1
DOIs
Publication statusPublished - Sep 9 1982

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Endorphins
Liver Diseases
Chronic Disease
Methionine Enkephalin
Brain
Substance P
Somatostatin
Hypothalamus
gamma-Aminobutyric Acid
Serotonin

Keywords

  • liver disease
  • β-endorphin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Panerai, A. E., Salerno, F., Baldissera, F., Martini, A., Di Giulio, A. M., & Mantegazza, P. (1982). Brain β-endorphin concentrations in experimental chronic liver disease. Brain Research, 247(1), 188-190. https://doi.org/10.1016/0006-8993(82)91049-6

Brain β-endorphin concentrations in experimental chronic liver disease. / Panerai, A. E.; Salerno, F.; Baldissera, F.; Martini, A.; Di Giulio, A. M.; Mantegazza, P.

In: Brain Research, Vol. 247, No. 1, 09.09.1982, p. 188-190.

Research output: Contribution to journalArticle

Panerai, AE, Salerno, F, Baldissera, F, Martini, A, Di Giulio, AM & Mantegazza, P 1982, 'Brain β-endorphin concentrations in experimental chronic liver disease', Brain Research, vol. 247, no. 1, pp. 188-190. https://doi.org/10.1016/0006-8993(82)91049-6
Panerai AE, Salerno F, Baldissera F, Martini A, Di Giulio AM, Mantegazza P. Brain β-endorphin concentrations in experimental chronic liver disease. Brain Research. 1982 Sep 9;247(1):188-190. https://doi.org/10.1016/0006-8993(82)91049-6
Panerai, A. E. ; Salerno, F. ; Baldissera, F. ; Martini, A. ; Di Giulio, A. M. ; Mantegazza, P. / Brain β-endorphin concentrations in experimental chronic liver disease. In: Brain Research. 1982 ; Vol. 247, No. 1. pp. 188-190.
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