TY - JOUR
T1 - Brain abscesses in children
T2 - an Italian multicentre study
AU - RAFFALDI, I.
AU - GARAZZINO, S.
AU - CASTELLI GATTINARA, G.
AU - LIPRERI, R.
AU - LANCELLA, L.
AU - ESPOSITO, S.
AU - GIANNINI, A. M.
AU - MONTAGNANI, C.
AU - MARSEGLIA, G. L.
AU - PIGNATA, C.
AU - BERNARDI, F.
AU - TOVO, P. A.
AU - SITIP BRAIN ABSCESSES REGISTRY
PY - 2017
Y1 - 2017
N2 - Brain abscess is uncommon in paediatric population, but of clinical importance because of significant long-term morbidity and mortality. In this multicentre study, promoted by the Italian Society for Paediatric Infectious Diseases, we retrospectively collected patients aged 0–18 years, with a diagnosis of ‘brain abscess’. Seventy-nine children were included; the median age was 8·75 years. As predisposing factor, 44 children had preceding infections. The Gram-positive cocci were mostly isolated (27 cases). Sixty (76%) children underwent a surgical intervention. Intravenous antibiotic therapy was administered in all patients, then switched to oral treatment. Clinical sequelae were recorded in 31 (39·2%) children. Twenty-one of them had a single sequela, of which, the most represented, was epilepsy in nine of them. This study focus the attention on the need to have standardized national guidelines or adequate recommendations on type and duration of antibiotic treatment.
AB - Brain abscess is uncommon in paediatric population, but of clinical importance because of significant long-term morbidity and mortality. In this multicentre study, promoted by the Italian Society for Paediatric Infectious Diseases, we retrospectively collected patients aged 0–18 years, with a diagnosis of ‘brain abscess’. Seventy-nine children were included; the median age was 8·75 years. As predisposing factor, 44 children had preceding infections. The Gram-positive cocci were mostly isolated (27 cases). Sixty (76%) children underwent a surgical intervention. Intravenous antibiotic therapy was administered in all patients, then switched to oral treatment. Clinical sequelae were recorded in 31 (39·2%) children. Twenty-one of them had a single sequela, of which, the most represented, was epilepsy in nine of them. This study focus the attention on the need to have standardized national guidelines or adequate recommendations on type and duration of antibiotic treatment.
KW - Anaerobic bacteria
KW - antibiotics
KW - bacterial infections
KW - central nervous system infections
KW - emerging infections
UR - http://www.scopus.com/inward/record.url?scp=85026878809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026878809&partnerID=8YFLogxK
U2 - 10.1017/S0950268817001583
DO - 10.1017/S0950268817001583
M3 - Article
AN - SCOPUS:85026878809
VL - 145
SP - 2848
EP - 2855
JO - Epidemiology and Infection
JF - Epidemiology and Infection
SN - 0950-2688
IS - 13
ER -