Brain abscesses in children: an Italian multicentre study

I. Raffaldi, S. Garazzino, G. Castelli Gattinara, R. Lipreri, L. Lancella, S. Esposito, A. M. Giannini, C. Montagnani, G. L. Marseglia, C. Pignata, F. Bernardi, P. A. Tovo, SITIP BRAIN ABSCESSES REGISTRY

Research output: Contribution to journalArticle

Abstract

Brain abscess is uncommon in paediatric population, but of clinical importance because of significant long-term morbidity and mortality. In this multicentre study, promoted by the Italian Society for Paediatric Infectious Diseases, we retrospectively collected patients aged 0-18 years, with a diagnosis of 'brain abscess'. Seventy-nine children were included; the median age was 8.75 years. As predisposing factor, 44 children had preceding infections. The Gram-positive cocci were mostly isolated (27 cases). Sixty (76%) children underwent a surgical intervention. Intravenous antibiotic therapy was administered in all patients, then switched to oral treatment. Clinical sequelae were recorded in 31 (39.2%) children. Twenty-one of them had a single sequela, of which, the most represented, was epilepsy in nine of them. This study focus the attention on the need to have standardized national guidelines or adequate recommendations on type and duration of antibiotic treatment.
Original languageEnglish
Pages (from-to)2848-2855
Number of pages8
JournalEpidemiology and Infection
Volume145
Issue number13
DOIs
Publication statusPublished - Oct 1 2017

Keywords

  • Adolescent
  • Anti-Bacterial Agents/pharmacology/therapeutic use
  • Bacteria/classification/drug effects/isolation & purification
  • Brain Abscess/drug therapy/epidemiology/microbiology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Italy/epidemiology
  • Male
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Treatment Outcome
  • Anaerobic bacteria
  • antibiotics
  • bacterial infections
  • central nervous system infections
  • emerging infections

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  • Cite this

    Raffaldi, I., Garazzino, S., Gattinara, G. C., Lipreri, R., Lancella, L., Esposito, S., Giannini, A. M., Montagnani, C., Marseglia, G. L., Pignata, C., Bernardi, F., Tovo, P. A., & REGISTRY, SITIP. BRAIN. ABSCESSES. (2017). Brain abscesses in children: an Italian multicentre study. Epidemiology and Infection, 145(13), 2848-2855. https://doi.org/10.1017/S0950268817001583 [doi]