Brain activity in rectosigmoid pain: Unravelling conditioning pain modulatory pathways

Christina Brock, Søren Schou Olesen, Massimiliano Valeriani, Lars Arendt-Nielsen, Asbjørn Mohr Drewes

Research output: Contribution to journalArticlepeer-review


Objective: Conditioning Pain Modulation (CPM) represents the various descending inhibitory mechanisms induced by a heterotopic noxious stimulation (previously termed DNIC). CPM-induced modulations in brain activity have not previously been investigated to visceral pain. Hence the aims were to assess the role of CPM in terms of: (1) psychophysics, (2) alterations in topography and amplitudes of evoked brain potentials and (3) modelling the brain activity. Methods: Fifteen healthy volunteers were stimulated electrically in the rectosigmoid, and 64-channel brain activity was recorded two times before (reproducibility), during and after induction of CPM by immersing the non-dominant hand into water at 2°C for 180. s (cold pressor). Results: During CPM pain scores were reduced in comparison to baseline (P≤0.001), which corresponds to 30% pain attenuation. In comparison to baseline significant differences in bipolar EEG topography were seen during CPM, where N2 moved from central to frontal activity (P

Original languageEnglish
Pages (from-to)829-837
Number of pages9
JournalClinical Neurophysiology
Issue number4
Publication statusPublished - Apr 2012


  • CPM
  • Descending pain control
  • DNIC
  • Evoked potentials
  • Neurophysiology
  • Psychophysical
  • Source modelling
  • Top-down pain matrix
  • Visceral pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems


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