Brain anatomy of persistent violent offenders: More rather than less

Jari Tiihonen, Roberta Rossi, Mikko P. Laakso, Sheilagh Hodgins, Cristina Testa, Jorge Perez, Eila Repo-Tiihonen, Olli Vaurio, Hilkka Soininen, Hannu J. Aronen, Mervi Könönen, Paul M. Thompson, Giovanni B. Frisoni

Research output: Contribution to journalArticle

Abstract

Most violent crimes in Western societies are committed by a small group of men who display antisocial behavior from an early age that remains stable across the life-span. It is not known if these men display abnormal brain structure. We compared regional brain volumes of 26 persistently violent offenders with antisocial personality disorder and substance dependence and 25 healthy men using magnetic resonance imaging volumetry and voxel-based morphometry (VBM). The violent offenders, as compared with the healthy men, had markedly larger white matter volumes, bilaterally, in the occipital and parietal lobes, and in the left cerebellum, and larger grey matter volume in right cerebellum (effect sizes up to 1.24, P <0.001). Among the offenders, volumes of these areas were not associated with psychopathy scores, substance abuse, psychotropic medication, or global IQ scores. By contrast, VBM analyses of grey matter revealed focal, symmetrical, bilateral areas of atrophy in the postcentral gyri, frontopolar cortex, and orbitofrontal cortex among the offenders as compared with the healthy men (z-scores as high as 5.06). Offenders with psychopathy showed the smallest volumes in these areas. The larger volumes in posterior brain areas may reflect atypical neurodevelopmental processes that underlie early-onset persistent antisocial and aggressive behavior.

Original languageEnglish
Pages (from-to)201-212
Number of pages12
JournalPsychiatry Research - Neuroimaging
Volume163
Issue number3
DOIs
Publication statusPublished - Aug 30 2008

Keywords

  • Aggression
  • Antisocial
  • MRI
  • Psychopathy
  • Violence
  • Volumetry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

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  • Cite this

    Tiihonen, J., Rossi, R., Laakso, M. P., Hodgins, S., Testa, C., Perez, J., Repo-Tiihonen, E., Vaurio, O., Soininen, H., Aronen, H. J., Könönen, M., Thompson, P. M., & Frisoni, G. B. (2008). Brain anatomy of persistent violent offenders: More rather than less. Psychiatry Research - Neuroimaging, 163(3), 201-212. https://doi.org/10.1016/j.pscychresns.2007.08.012