Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease

Francesca Gelfo, Paola Tirassa, Paola De Bartolo, Carlo Caltagirone, Laura Petrosini, Francesco Angelucci

Research output: Contribution to journalArticle

Abstract

Different Alzheimer's disease (AD) stages may be characterized by different directions in nerve growth factor (NGF) changes, suggesting that NGF may serve as peripheral marker of AD. To characterize the time course of NGF changes in an AD animal model, we measured NGF brain and serum levels at 3, 7, and 15 days from cholinergic depletion. NGF levels increased in the frontal cortex and hippocampus at 3 and 7 days and decreased in the serum at 7 days from lesion, suggesting that opposite changes in brain and serum occur at early stages of cholinergic depletion. When compared to human data, these findings further elucidate the role of NGF in early and late AD disease stages.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalJournal of Alzheimer's Disease
Volume25
Issue number2
DOIs
Publication statusPublished - 2011

Keywords

  • ChAT
  • cholinergic neurons
  • neurotrophins
  • Saporin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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