Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats

Alberto E. Panerai, Paola Sacerdote, Mauro Bianchi, Anna Brini, Paolo Mantegazza

Research output: Contribution to journalArticlepeer-review


The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalLife Sciences
Issue number10
Publication statusPublished - Sep 7 1987

ASJC Scopus subject areas

  • Pharmacology


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