Abstract
The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.
| Original language | English |
|---|---|
| Pages (from-to) | 1297-1303 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 41 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Sep 7 1987 |
Fingerprint
ASJC Scopus subject areas
- Pharmacology
Cite this
Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats. / Panerai, Alberto E.; Sacerdote, Paola; Bianchi, Mauro; Brini, Anna; Mantegazza, Paolo.
In: Life Sciences, Vol. 41, No. 10, 07.09.1987, p. 1297-1303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats
AU - Panerai, Alberto E.
AU - Sacerdote, Paola
AU - Bianchi, Mauro
AU - Brini, Anna
AU - Mantegazza, Paolo
PY - 1987/9/7
Y1 - 1987/9/7
N2 - The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.
AB - The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.
UR - http://www.scopus.com/inward/record.url?scp=0023239622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023239622&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(87)90209-8
DO - 10.1016/0024-3205(87)90209-8
M3 - Article
C2 - 2442576
AN - SCOPUS:0023239622
VL - 41
SP - 1297
EP - 1303
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 10
ER -