Abstract
The concentrations of brain and spinal cord beta-endorphin, met-enkephalin, dynorphin and substance P were measured in rats bearing the Freund adjuvant induced arthritis. Beta-endorphin brain concentrations decreased gradually in time with a nadir on day twenty-one, when arthritis was at its maximum, and were back to normal by day thirty-five, when arthritis was no more evident. Met-enkephalin concentrations increased in brain areas and in the lumbar spinal cord and returned to normal with the same time pattern, while dynorphin and substance P concentrations did not change. These data indicate that peripheral lesions can induce important changes in brain concentrations of some opioid peptides involved in the modulation of pain.
| Original language | English |
|---|---|
| Pages (from-to) | 1297-1303 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 41 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Sep 7 1987 |
ASJC Scopus subject areas
- Pharmacology
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Cite this
Panerai, A. E., Sacerdote, P., Bianchi, M., Brini, A., & Mantegazza, P. (1987). Brain and spinal cord neuropeptides in adjuvant induced arthritis in rats. Life Sciences, 41(10), 1297-1303. https://doi.org/10.1016/0024-3205(87)90209-8