Brain atrophy and cerebral small vessel disease a prospective follow-up study

Arani Nitkunan, Silvia Lanfranconi, Rebecca A. Charlton, Thomas R. Barrick, Hugh S. Markus

Research output: Contribution to journalArticlepeer-review


Background and Purpose-Cerebral small vessel disease (SVD) is the most common cause of vascular dementia. Interest in the use of surrogate markers is increasing. The aims of this study were to determine if brain volume was different between patients with SVD and control subjects, whether it correlated with cognition in SVD, and whether changes in brain volume could be detected during prospective follow-up. Methods-Thirty-five patients (mean age, 68.8 years) who had a lacunar stroke and radiological evidence of confluent leukoaraiosis and 70 age- and gender-matched control subjects were recruited. Whole-brain T1-weighted imaging and neuropsychological testing were performed after 1 year on all patients and after 2 years for the control subjects. Fully automated software was used to determine brain volume and percentage brain volume change. An executive function score was derived. Results-There was a significant difference in brain volume between the patients with SVD and control subjects (mean±SD [mL] 1529±84 versus 1573±69, P=0.019). In the patients with SVD, there was a significant association between brain volume and executive function (r=0.501, P

Original languageEnglish
Pages (from-to)133-138
Number of pages6
Issue number1
Publication statusPublished - Jan 2011


  • Brain atrophy
  • Cerebral small vessel disease
  • Cognitive impairment
  • Longitudinal study
  • MRI
  • Surrogate marker

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing


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