Abstract
Recent MRI studies in multiple sclerosis have highlighted the potential role of brain atrophy evaluation as a putative marker of disease progression. In the present study, we evaluated the supratentorial and infratentorial brain volume in patients with relapsing remitting multiple sclerosis (RR MS) and in healthy subjects. Moreover, we determined whether brain volumes of MS patients are associated with different aspects of brain MRI abnormalities and clinical findings. Two-dimensional acquired MRI was performed on 52 relapsing-remitting multiple sclerosis and 30 healthy subjects. The volume of supratentorial and infratentorial structures was measured in selected representative slices. Gd-enhancement, T2 hyperintense, T1 hypointense (i.e. 'black holes') total lesion load, as well as the area of corpus callosum was calculated in the MS group and related to brain volume measures. Correlations between MRI parameters and clinical features were also considered. MS patients had significantly lower supratentorial, infratentorial brain volume and corpus callosum area than healthy subjects (P
| Original language | English |
|---|---|
| Pages (from-to) | 85-91 |
| Number of pages | 7 |
| Journal | Journal of the Neurological Sciences |
| Volume | 174 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 15 2000 |
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Keywords
- Brain atrophy
- EDSS
- Magnetic resonance
- Multiple sclerosis
ASJC Scopus subject areas
- Ageing
- Clinical Neurology
- Surgery
- Neuroscience(all)
- Developmental Neuroscience
- Neurology
Cite this
Brain atrophy in relapsing-remitting multiple sclerosis : Relationship with 'black holes', disease duration and clinical disability. / Paolillo, Andrea; Pozzilli, Carlo; Gasperini, Claudio; Giugni, Elisabetta; Mainero, Caterina; Giuliani, Saverio; Tomassini, Valentina; Millefiorini, Enrico; Bastianello, Stefane.
In: Journal of the Neurological Sciences, Vol. 174, No. 2, 15.03.2000, p. 85-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain atrophy in relapsing-remitting multiple sclerosis
T2 - Relationship with 'black holes', disease duration and clinical disability
AU - Paolillo, Andrea
AU - Pozzilli, Carlo
AU - Gasperini, Claudio
AU - Giugni, Elisabetta
AU - Mainero, Caterina
AU - Giuliani, Saverio
AU - Tomassini, Valentina
AU - Millefiorini, Enrico
AU - Bastianello, Stefane
PY - 2000/3/15
Y1 - 2000/3/15
N2 - Recent MRI studies in multiple sclerosis have highlighted the potential role of brain atrophy evaluation as a putative marker of disease progression. In the present study, we evaluated the supratentorial and infratentorial brain volume in patients with relapsing remitting multiple sclerosis (RR MS) and in healthy subjects. Moreover, we determined whether brain volumes of MS patients are associated with different aspects of brain MRI abnormalities and clinical findings. Two-dimensional acquired MRI was performed on 52 relapsing-remitting multiple sclerosis and 30 healthy subjects. The volume of supratentorial and infratentorial structures was measured in selected representative slices. Gd-enhancement, T2 hyperintense, T1 hypointense (i.e. 'black holes') total lesion load, as well as the area of corpus callosum was calculated in the MS group and related to brain volume measures. Correlations between MRI parameters and clinical features were also considered. MS patients had significantly lower supratentorial, infratentorial brain volume and corpus callosum area than healthy subjects (P
AB - Recent MRI studies in multiple sclerosis have highlighted the potential role of brain atrophy evaluation as a putative marker of disease progression. In the present study, we evaluated the supratentorial and infratentorial brain volume in patients with relapsing remitting multiple sclerosis (RR MS) and in healthy subjects. Moreover, we determined whether brain volumes of MS patients are associated with different aspects of brain MRI abnormalities and clinical findings. Two-dimensional acquired MRI was performed on 52 relapsing-remitting multiple sclerosis and 30 healthy subjects. The volume of supratentorial and infratentorial structures was measured in selected representative slices. Gd-enhancement, T2 hyperintense, T1 hypointense (i.e. 'black holes') total lesion load, as well as the area of corpus callosum was calculated in the MS group and related to brain volume measures. Correlations between MRI parameters and clinical features were also considered. MS patients had significantly lower supratentorial, infratentorial brain volume and corpus callosum area than healthy subjects (P
KW - Brain atrophy
KW - EDSS
KW - Magnetic resonance
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=0034653442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034653442&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(00)00259-8
DO - 10.1016/S0022-510X(00)00259-8
M3 - Article
C2 - 10727693
AN - SCOPUS:0034653442
VL - 174
SP - 85
EP - 91
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 2
ER -