Brain atrophy in relapsing-remitting multiple sclerosis: Relationship with 'black holes', disease duration and clinical disability

Andrea Paolillo, Carlo Pozzilli, Claudio Gasperini, Elisabetta Giugni, Caterina Mainero, Saverio Giuliani, Valentina Tomassini, Enrico Millefiorini, Stefane Bastianello

Research output: Contribution to journalArticle

Abstract

Recent MRI studies in multiple sclerosis have highlighted the potential role of brain atrophy evaluation as a putative marker of disease progression. In the present study, we evaluated the supratentorial and infratentorial brain volume in patients with relapsing remitting multiple sclerosis (RR MS) and in healthy subjects. Moreover, we determined whether brain volumes of MS patients are associated with different aspects of brain MRI abnormalities and clinical findings. Two-dimensional acquired MRI was performed on 52 relapsing-remitting multiple sclerosis and 30 healthy subjects. The volume of supratentorial and infratentorial structures was measured in selected representative slices. Gd-enhancement, T2 hyperintense, T1 hypointense (i.e. 'black holes') total lesion load, as well as the area of corpus callosum was calculated in the MS group and related to brain volume measures. Correlations between MRI parameters and clinical features were also considered. MS patients had significantly lower supratentorial, infratentorial brain volume and corpus callosum area than healthy subjects (P

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalJournal of the Neurological Sciences
Volume174
Issue number2
DOIs
Publication statusPublished - Mar 15 2000

Keywords

  • Brain atrophy
  • EDSS
  • Magnetic resonance
  • Multiple sclerosis

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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