Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men

Paul E. Sijens, Tom Den Heijer, Daniela Origgi, Sarah E. Vermeer, Monique M B Breteler, Albert Hofman, Matthijs Oudkerk

Research output: Contribution to journalArticle

Abstract

PURPOSE: To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men. MATERIALS AND METHODS: A transverse plane above the ventricle of the brain was mapped with magnetic resonance spectroscopy. Examinations were performed in 1995-1996 with 271 healthy subjects (age range, 60-90 years; mean age, 73 years) and were repeated 4 years later (1999-2000). Student t tests were used for statistical analysis. RESULTS: Difference analysis of the changes in 4 years (paired data) reproduced the decrease in Cho in women only (2.9% per year, P <.001) that had been indicated with intersubject correlation analyses. Decreases in NAA, though significant in both men and women according to age correlation analyses (P <.01 for both), did not reach significance. The resulting sex difference in the Cho/NAA ratio at a mean age of 77 years, while not yet significant at a mean age of 73 years, was especially manifest in the posterior half of the plane analyzed. CONCLUSION: Increasing sex differences in Cho/NAA ratios in a supraventricular plane indicate that brain metabolite levels differ between women and men at advanced age.

Original languageEnglish
Pages (from-to)889-896
Number of pages8
JournalRadiology
Volume226
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Fingerprint

Choline
Magnetic Resonance Spectroscopy
Brain
Sex Characteristics
Creatine
Healthy Volunteers
Students
N-acetylaspartate

Keywords

  • Aging
  • Brain
  • Magnetic resonance (MR)
  • Metabolism
  • Spectroscopy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Sijens, P. E., Den Heijer, T., Origgi, D., Vermeer, S. E., Breteler, M. M. B., Hofman, A., & Oudkerk, M. (2003). Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. Radiology, 226(3), 889-896. https://doi.org/10.1148/radiol.2263011937

Brain changes with aging : MR spectroscopy at supraventricular plane shows differences between women and men. / Sijens, Paul E.; Den Heijer, Tom; Origgi, Daniela; Vermeer, Sarah E.; Breteler, Monique M B; Hofman, Albert; Oudkerk, Matthijs.

In: Radiology, Vol. 226, No. 3, 01.03.2003, p. 889-896.

Research output: Contribution to journalArticle

Sijens, PE, Den Heijer, T, Origgi, D, Vermeer, SE, Breteler, MMB, Hofman, A & Oudkerk, M 2003, 'Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men', Radiology, vol. 226, no. 3, pp. 889-896. https://doi.org/10.1148/radiol.2263011937
Sijens, Paul E. ; Den Heijer, Tom ; Origgi, Daniela ; Vermeer, Sarah E. ; Breteler, Monique M B ; Hofman, Albert ; Oudkerk, Matthijs. / Brain changes with aging : MR spectroscopy at supraventricular plane shows differences between women and men. In: Radiology. 2003 ; Vol. 226, No. 3. pp. 889-896.
@article{f8d5e7cb829f42ae830219f3cd91f3ec,
title = "Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men",
abstract = "PURPOSE: To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men. MATERIALS AND METHODS: A transverse plane above the ventricle of the brain was mapped with magnetic resonance spectroscopy. Examinations were performed in 1995-1996 with 271 healthy subjects (age range, 60-90 years; mean age, 73 years) and were repeated 4 years later (1999-2000). Student t tests were used for statistical analysis. RESULTS: Difference analysis of the changes in 4 years (paired data) reproduced the decrease in Cho in women only (2.9{\%} per year, P <.001) that had been indicated with intersubject correlation analyses. Decreases in NAA, though significant in both men and women according to age correlation analyses (P <.01 for both), did not reach significance. The resulting sex difference in the Cho/NAA ratio at a mean age of 77 years, while not yet significant at a mean age of 73 years, was especially manifest in the posterior half of the plane analyzed. CONCLUSION: Increasing sex differences in Cho/NAA ratios in a supraventricular plane indicate that brain metabolite levels differ between women and men at advanced age.",
keywords = "Aging, Brain, Magnetic resonance (MR), Metabolism, Spectroscopy",
author = "Sijens, {Paul E.} and {Den Heijer}, Tom and Daniela Origgi and Vermeer, {Sarah E.} and Breteler, {Monique M B} and Albert Hofman and Matthijs Oudkerk",
year = "2003",
month = "3",
day = "1",
doi = "10.1148/radiol.2263011937",
language = "English",
volume = "226",
pages = "889--896",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "3",

}

TY - JOUR

T1 - Brain changes with aging

T2 - MR spectroscopy at supraventricular plane shows differences between women and men

AU - Sijens, Paul E.

AU - Den Heijer, Tom

AU - Origgi, Daniela

AU - Vermeer, Sarah E.

AU - Breteler, Monique M B

AU - Hofman, Albert

AU - Oudkerk, Matthijs

PY - 2003/3/1

Y1 - 2003/3/1

N2 - PURPOSE: To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men. MATERIALS AND METHODS: A transverse plane above the ventricle of the brain was mapped with magnetic resonance spectroscopy. Examinations were performed in 1995-1996 with 271 healthy subjects (age range, 60-90 years; mean age, 73 years) and were repeated 4 years later (1999-2000). Student t tests were used for statistical analysis. RESULTS: Difference analysis of the changes in 4 years (paired data) reproduced the decrease in Cho in women only (2.9% per year, P <.001) that had been indicated with intersubject correlation analyses. Decreases in NAA, though significant in both men and women according to age correlation analyses (P <.01 for both), did not reach significance. The resulting sex difference in the Cho/NAA ratio at a mean age of 77 years, while not yet significant at a mean age of 73 years, was especially manifest in the posterior half of the plane analyzed. CONCLUSION: Increasing sex differences in Cho/NAA ratios in a supraventricular plane indicate that brain metabolite levels differ between women and men at advanced age.

AB - PURPOSE: To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men. MATERIALS AND METHODS: A transverse plane above the ventricle of the brain was mapped with magnetic resonance spectroscopy. Examinations were performed in 1995-1996 with 271 healthy subjects (age range, 60-90 years; mean age, 73 years) and were repeated 4 years later (1999-2000). Student t tests were used for statistical analysis. RESULTS: Difference analysis of the changes in 4 years (paired data) reproduced the decrease in Cho in women only (2.9% per year, P <.001) that had been indicated with intersubject correlation analyses. Decreases in NAA, though significant in both men and women according to age correlation analyses (P <.01 for both), did not reach significance. The resulting sex difference in the Cho/NAA ratio at a mean age of 77 years, while not yet significant at a mean age of 73 years, was especially manifest in the posterior half of the plane analyzed. CONCLUSION: Increasing sex differences in Cho/NAA ratios in a supraventricular plane indicate that brain metabolite levels differ between women and men at advanced age.

KW - Aging

KW - Brain

KW - Magnetic resonance (MR)

KW - Metabolism

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=0037371417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037371417&partnerID=8YFLogxK

U2 - 10.1148/radiol.2263011937

DO - 10.1148/radiol.2263011937

M3 - Article

C2 - 12601215

AN - SCOPUS:0037371417

VL - 226

SP - 889

EP - 896

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

ER -