Abstract
Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.
Original language | English |
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Pages (from-to) | 377-381 |
Number of pages | 5 |
Journal | Life Sciences |
Volume | 33 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1983 |
ASJC Scopus subject areas
- Pharmacology