Abstract
Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.
| Original language | English |
|---|---|
| Pages (from-to) | 377-381 |
| Number of pages | 5 |
| Journal | Life Sciences |
| Volume | 33 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1983 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis. / Salerno, F.; Bonato, C.; Panerai, A. E.; Martini, A.; Malesci, A.
In: Life Sciences, Vol. 33, No. 4, 1983, p. 377-381.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis
AU - Salerno, F.
AU - Bonato, C.
AU - Panerai, A. E.
AU - Martini, A.
AU - Malesci, A.
PY - 1983
Y1 - 1983
N2 - Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.
AB - Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.
UR - http://www.scopus.com/inward/record.url?scp=84878779762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878779762&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(83)80012-5
DO - 10.1016/S0024-3205(83)80012-5
M3 - Article
C2 - 6308371
AN - SCOPUS:84878779762
VL - 33
SP - 377
EP - 381
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 4
ER -