Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

F. Salerno; C. Bonato; A. E. Panerai; A. Martini; A. Malesci

doi:10.1016/S0024-3205(83)80012-5

Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

F. Salerno, C. Bonato, A. E. Panerai, A. Martini, A. Malesci

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Abstract

Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

Original language	English
Pages (from-to)	377-381
Number of pages	5
Journal	Life Sciences
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/S0024-3205(83)80012-5
Publication status	Published - 1983

ASJC Scopus subject areas

Pharmacology

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10.1016/S0024-3205(83)80012-5

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title = "Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis",

abstract = "Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.",

author = "F. Salerno and C. Bonato and Panerai, {A. E.} and A. Martini and A. Malesci",

year = "1983",

doi = "10.1016/S0024-3205(83)80012-5",

language = "English",

volume = "33",

pages = "377--381",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

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T1 - Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

AU - Salerno, F.

AU - Bonato, C.

AU - Panerai, A. E.

AU - Martini, A.

AU - Malesci, A.

PY - 1983

Y1 - 1983

N2 - Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

AB - Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

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U2 - 10.1016/S0024-3205(83)80012-5

DO - 10.1016/S0024-3205(83)80012-5

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SP - 377

EP - 381

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 4

ER -

Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

Abstract

ASJC Scopus subject areas

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