Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

F. Salerno, C. Bonato, A. E. Panerai, A. Martini, A. Malesci

Research output: Contribution to journalArticlepeer-review


Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalLife Sciences
Issue number4
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Pharmacology


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