Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

F. Salerno, C. Bonato, A. E. Panerai, A. Martini, A. Malesci

Research output: Contribution to journalArticle

Abstract

Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

Original languageEnglish
Pages (from-to)377-381
Number of pages5
JournalLife Sciences
Volume33
Issue number4
DOIs
Publication statusPublished - 1983

Fingerprint

Experimental Liver Cirrhosis
Liver
Rats
Brain
Endorphins
Sincalide
End Stage Liver Disease
Fractionation
Neuropeptides
Hypothalamus
Animals
cholecystokinin 8

ASJC Scopus subject areas

  • Pharmacology

Cite this

Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis. / Salerno, F.; Bonato, C.; Panerai, A. E.; Martini, A.; Malesci, A.

In: Life Sciences, Vol. 33, No. 4, 1983, p. 377-381.

Research output: Contribution to journalArticle

Salerno, F. ; Bonato, C. ; Panerai, A. E. ; Martini, A. ; Malesci, A. / Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis. In: Life Sciences. 1983 ; Vol. 33, No. 4. pp. 377-381.
@article{603597a5a00443ac941dc76df41bad65,
title = "Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis",
abstract = "Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.",
author = "F. Salerno and C. Bonato and Panerai, {A. E.} and A. Martini and A. Malesci",
year = "1983",
doi = "10.1016/S0024-3205(83)80012-5",
language = "English",
volume = "33",
pages = "377--381",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Brain cholecystokinin-8 immunoreactivity in rats with experimental liver cirrhosis

AU - Salerno, F.

AU - Bonato, C.

AU - Panerai, A. E.

AU - Martini, A.

AU - Malesci, A.

PY - 1983

Y1 - 1983

N2 - Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

AB - Cholecystokinin-8 like immunoreactivity (CCK-8 IR) was measured in different brain regions of rats with experimental liver cirrhosis. A statistically significant reduction of CCK-8 content was observed in the hypothalamus of cirrhotic rats. No significant modification of brain CCK fractionation pattern was observed in treated animals as compared to controls. The decrease of CCK-8 IR parallels the recently reported hypothalamic depletion of βendorphin in cirrhotic rats confirming the central neuropeptides are affected by chronic liver failure.

UR - http://www.scopus.com/inward/record.url?scp=84878779762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878779762&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(83)80012-5

DO - 10.1016/S0024-3205(83)80012-5

M3 - Article

C2 - 6308371

AN - SCOPUS:84878779762

VL - 33

SP - 377

EP - 381

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 4

ER -