Brain-computer interface in paralysis

Niels Birbaumer, Ander Ramos Murguialday, Leonardo Cohen

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Purpose of review: Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge. Movement restoration for patients with chronic stroke or other brain damage also remains a therapeutic problem and available treatments do not offer significant improvements. This review considers recent research in brain-computer interfaces (BCIs) as promising solutions to these challenges. Recent findings: Experimentation with nonhuman primates suggests that intentional goal directed movements of the upper limbs can be reconstructed and transmitted to external manipulandum or robotic devices controlled from a relatively small number of microelectrodes implanted into movement-relevant brain areas after some training, opening the door for the development of BCI or brain-machine interfaces in humans. Although noninvasive BCIs using electroencephalographic recordings or event-related-brain-potentials in healthy individuals and patients with amyotrophic lateral sclerosis or stroke can transmit up to 80 bits/min of information, the use of BCIs - invasive or noninvasive - in severely or totally paralyzed patients has met some unforeseen difficulties. Summary: Invasive and noninvasive BCIs using recordings from nerve cells, large neuronal pools such as electrocorticogram and electroencephalography, or blood flow based measures such as functional magnetic resonance imaging and near-infrared spectroscopy show potential for communication in locked-in syndrome and movement restoration in chronic stroke, but controlled phase III clinical trials with larger populations of severely disturbed patients are urgently needed.

Original languageEnglish
Pages (from-to)634-638
Number of pages5
JournalCurrent Opinion in Neurology
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Brain-Computer Interfaces
Paralysis
Quadriplegia
Stroke
Brain
Communication
Phase III Clinical Trials
Near-Infrared Spectroscopy
Controlled Clinical Trials
Amyotrophic Lateral Sclerosis
Robotics
Microelectrodes
Evoked Potentials
Upper Extremity
Primates
Electroencephalography
Magnetic Resonance Imaging
Neurons
Equipment and Supplies
Therapeutics

Keywords

  • Amyotrophic lateral sclerosis
  • Movement restoration
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Birbaumer, N., Murguialday, A. R., & Cohen, L. (2008). Brain-computer interface in paralysis. Current Opinion in Neurology, 21(6), 634-638. https://doi.org/10.1097/WCO.0b013e328315ee2d

Brain-computer interface in paralysis. / Birbaumer, Niels; Murguialday, Ander Ramos; Cohen, Leonardo.

In: Current Opinion in Neurology, Vol. 21, No. 6, 12.2008, p. 634-638.

Research output: Contribution to journalArticle

Birbaumer, N, Murguialday, AR & Cohen, L 2008, 'Brain-computer interface in paralysis', Current Opinion in Neurology, vol. 21, no. 6, pp. 634-638. https://doi.org/10.1097/WCO.0b013e328315ee2d
Birbaumer, Niels ; Murguialday, Ander Ramos ; Cohen, Leonardo. / Brain-computer interface in paralysis. In: Current Opinion in Neurology. 2008 ; Vol. 21, No. 6. pp. 634-638.
@article{9e04097ba851400ab5d74c41f3cb7651,
title = "Brain-computer interface in paralysis",
abstract = "Purpose of review: Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge. Movement restoration for patients with chronic stroke or other brain damage also remains a therapeutic problem and available treatments do not offer significant improvements. This review considers recent research in brain-computer interfaces (BCIs) as promising solutions to these challenges. Recent findings: Experimentation with nonhuman primates suggests that intentional goal directed movements of the upper limbs can be reconstructed and transmitted to external manipulandum or robotic devices controlled from a relatively small number of microelectrodes implanted into movement-relevant brain areas after some training, opening the door for the development of BCI or brain-machine interfaces in humans. Although noninvasive BCIs using electroencephalographic recordings or event-related-brain-potentials in healthy individuals and patients with amyotrophic lateral sclerosis or stroke can transmit up to 80 bits/min of information, the use of BCIs - invasive or noninvasive - in severely or totally paralyzed patients has met some unforeseen difficulties. Summary: Invasive and noninvasive BCIs using recordings from nerve cells, large neuronal pools such as electrocorticogram and electroencephalography, or blood flow based measures such as functional magnetic resonance imaging and near-infrared spectroscopy show potential for communication in locked-in syndrome and movement restoration in chronic stroke, but controlled phase III clinical trials with larger populations of severely disturbed patients are urgently needed.",
keywords = "Amyotrophic lateral sclerosis, Movement restoration, Stroke",
author = "Niels Birbaumer and Murguialday, {Ander Ramos} and Leonardo Cohen",
year = "2008",
month = "12",
doi = "10.1097/WCO.0b013e328315ee2d",
language = "English",
volume = "21",
pages = "634--638",
journal = "Current Opinion in Neurology",
issn = "1350-7540",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Brain-computer interface in paralysis

AU - Birbaumer, Niels

AU - Murguialday, Ander Ramos

AU - Cohen, Leonardo

PY - 2008/12

Y1 - 2008/12

N2 - Purpose of review: Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge. Movement restoration for patients with chronic stroke or other brain damage also remains a therapeutic problem and available treatments do not offer significant improvements. This review considers recent research in brain-computer interfaces (BCIs) as promising solutions to these challenges. Recent findings: Experimentation with nonhuman primates suggests that intentional goal directed movements of the upper limbs can be reconstructed and transmitted to external manipulandum or robotic devices controlled from a relatively small number of microelectrodes implanted into movement-relevant brain areas after some training, opening the door for the development of BCI or brain-machine interfaces in humans. Although noninvasive BCIs using electroencephalographic recordings or event-related-brain-potentials in healthy individuals and patients with amyotrophic lateral sclerosis or stroke can transmit up to 80 bits/min of information, the use of BCIs - invasive or noninvasive - in severely or totally paralyzed patients has met some unforeseen difficulties. Summary: Invasive and noninvasive BCIs using recordings from nerve cells, large neuronal pools such as electrocorticogram and electroencephalography, or blood flow based measures such as functional magnetic resonance imaging and near-infrared spectroscopy show potential for communication in locked-in syndrome and movement restoration in chronic stroke, but controlled phase III clinical trials with larger populations of severely disturbed patients are urgently needed.

AB - Purpose of review: Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge. Movement restoration for patients with chronic stroke or other brain damage also remains a therapeutic problem and available treatments do not offer significant improvements. This review considers recent research in brain-computer interfaces (BCIs) as promising solutions to these challenges. Recent findings: Experimentation with nonhuman primates suggests that intentional goal directed movements of the upper limbs can be reconstructed and transmitted to external manipulandum or robotic devices controlled from a relatively small number of microelectrodes implanted into movement-relevant brain areas after some training, opening the door for the development of BCI or brain-machine interfaces in humans. Although noninvasive BCIs using electroencephalographic recordings or event-related-brain-potentials in healthy individuals and patients with amyotrophic lateral sclerosis or stroke can transmit up to 80 bits/min of information, the use of BCIs - invasive or noninvasive - in severely or totally paralyzed patients has met some unforeseen difficulties. Summary: Invasive and noninvasive BCIs using recordings from nerve cells, large neuronal pools such as electrocorticogram and electroencephalography, or blood flow based measures such as functional magnetic resonance imaging and near-infrared spectroscopy show potential for communication in locked-in syndrome and movement restoration in chronic stroke, but controlled phase III clinical trials with larger populations of severely disturbed patients are urgently needed.

KW - Amyotrophic lateral sclerosis

KW - Movement restoration

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=56749127998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749127998&partnerID=8YFLogxK

U2 - 10.1097/WCO.0b013e328315ee2d

DO - 10.1097/WCO.0b013e328315ee2d

M3 - Article

C2 - 18989104

AN - SCOPUS:56749127998

VL - 21

SP - 634

EP - 638

JO - Current Opinion in Neurology

JF - Current Opinion in Neurology

SN - 1350-7540

IS - 6

ER -