Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity

S. Caccia, G. Guiso, S. Garattini

Research output: Contribution to journal › Article

Abstract

The results indicate that the antileptazol effect in mice is mediated by both clobazam and N-desmethylclobazam. Since the metabolite has a longer half-life than the parent compound, this probably explains why the antileptazol effect is longer in animal species in which N-desmethylclobazam is accumulated in significant amounts.

Original languageEnglish
Pages (from-to)295-296
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume32
Issue number4
Publication statusPublished - 1980

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Brain
Half-Life
clobazam
N-desmethylclobazam

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity. / Caccia, S.; Guiso, G.; Garattini, S.

In: Journal of Pharmacy and Pharmacology, Vol. 32, No. 4, 1980, p. 295-296.

Research output: Contribution to journal › Article

Caccia, S, Guiso, G & Garattini, S 1980, 'Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity', Journal of Pharmacy and Pharmacology, vol. 32, no. 4, pp. 295-296.
Caccia S, Guiso G, Garattini S. Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity. Journal of Pharmacy and Pharmacology. 1980;32(4):295-296.
Caccia, S. ; Guiso, G. ; Garattini, S. / Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity. In: Journal of Pharmacy and Pharmacology. 1980 ; Vol. 32, No. 4. pp. 295-296.
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