Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity

S. Caccia; G. Guiso; S. Garattini

Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity

S. Caccia, G. Guiso, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The results indicate that the antileptazol effect in mice is mediated by both clobazam and N-desmethylclobazam. Since the metabolite has a longer half-life than the parent compound, this probably explains why the antileptazol effect is longer in animal species in which N-desmethylclobazam is accumulated in significant amounts.

Original language	English
Pages (from-to)	295-296
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	32
Issue number	4
Publication status	Published - 1980

ASJC Scopus subject areas

Pharmaceutical Science
Pharmacology

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title = "Brain concentrations of clobazam and N-desmethylclobazam and antileptazol activity",

abstract = "The results indicate that the antileptazol effect in mice is mediated by both clobazam and N-desmethylclobazam. Since the metabolite has a longer half-life than the parent compound, this probably explains why the antileptazol effect is longer in animal species in which N-desmethylclobazam is accumulated in significant amounts.",

author = "S. Caccia and G. Guiso and S. Garattini",

year = "1980",

language = "English",

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AU - Caccia, S.

AU - Guiso, G.

AU - Garattini, S.

PY - 1980

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N2 - The results indicate that the antileptazol effect in mice is mediated by both clobazam and N-desmethylclobazam. Since the metabolite has a longer half-life than the parent compound, this probably explains why the antileptazol effect is longer in animal species in which N-desmethylclobazam is accumulated in significant amounts.

AB - The results indicate that the antileptazol effect in mice is mediated by both clobazam and N-desmethylclobazam. Since the metabolite has a longer half-life than the parent compound, this probably explains why the antileptazol effect is longer in animal species in which N-desmethylclobazam is accumulated in significant amounts.

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