Brain connectivity changes after osteopathic manipulative treatment: A randomized manual placebo-controlled trial

Marco Tramontano, Francesco Cerritelli, Federica Piras, Barbara Spanò, Federica Tamburella, Fabrizio Piras, Carlo Caltagirone, Tommaso Gili

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of osteopathic manipulative treatment (OMT) on functional brain connectivity in healthy adults is missing in the literature. To make up for this lack, we applied advanced network analysis methods to analyze resting state functional magnetic resonance imaging (fMRI) data, after OMT and Placebo treatment (P) in 30 healthy asymptomatic young participants randomized into OMT and placebo groups (OMTg; Pg). fMRI brain activity measures, performed before (T0), immediately after (T1) and three days after (T2) OMT or P were used for inferring treatment effects on brain circuit functional organization. Repeated measures ANOVA and post-hoc analysis demonstrated that Right Precentral Gyrus (F (2, 32) = 5.995, p < 0.005) was more influential over the information flow immediately after the OMT, while decreased betweenness centrality in Left Caudate (F (2, 32) = 6.496, p < 0.005) was observable three days after. Clustering coefficient showed a distinct time-point and group effect. At T1, reduced neighborhood connectivity was observed after OMT in the Left Amygdala (L-Amyg) (F(2, 32) = 7.269, p < 0.005) and Left Middle Temporal Gyrus (F(2, 32) = 6.452, p < 0.005), whereas at T2 the L-Amyg and Vermis-III (F(2, 32) = 6.772, p < 0.005) increased functional interactions. Data demonstrated functional connectivity re-arrangement after OMT.

Original languageEnglish
Article number969
Pages (from-to)1-15
Number of pages15
JournalBrain Sciences
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • FMRI
  • Functional connectivity
  • Osteopathic manipulative treatment
  • Placebo
  • Somatic dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

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