Brain Connectivity Modulation after Exoskeleton-Assisted Gait in Chronic Hemiplegic Stroke Survivors: A Pilot Study

Franco Molteni, Emanuela Formaggio, Anna Bosco, Eleonora Guanziroli, Francesco Piccione, Stefano Masiero, Alessandra Del Felice

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The aim of this study was to investigate electroencephalographic (EEG) connectivity short-term changes, quantified by node strength and betweenness centrality, induced by a single trial of exoskeleton-assisted gait in chronic stroke survivors. Design Study design was randomized crossover. Electroencephalographic data (64-channel system) were recorded before gait (baseline) and after unassisted overground walking and overground exoskeleton-assisted walking. Coherence was estimated for alpha1, alpha2, and beta frequency ranges. Graph analysis assessed network model properties: node strength and betweenness centrality. Results Nine participants were included in the final analysis. In the group (four participants) with a left-hemisphere stroke lesion (dominant hemisphere), over the vertex, node strength increased in alpha1, alpha2, and beta bands, and betweenness centrality decreased in alpha2 both after unassisted overground walking and exoskeleton-assisted walking. In the group (five participants) with a right-hemisphere lesion (nondominant hemisphere), node strength increased in alpha1 and alpha2 over the contralesional sensorimotor area and ipsilesional prefrontal area after overground exoskeleton-assisted walking, compared with baseline and unassisted overground walking. Conclusion A single session of exoskeleton training provides short-term neuroplastic modulation in chronic stroke. In participants with a nondominant hemisphere lesion, exoskeleton training induces activations similar to those observed in able-bodied participants, suggesting a role of lesion lateralization in networks' reorganization.

Original languageEnglish
Pages (from-to)694-700
Number of pages7
JournalAmerican Journal of Physical Medicine and Rehabilitation
Volume99
Issue number8
DOIs
Publication statusPublished - Aug 1 2020

Keywords

  • EEG
  • Graph Analysis
  • Hemispheric Lateralization
  • Rehabilitation
  • Stroke

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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