Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder

S Poletti, V Aggio, TA Hoogenboezem, O Ambrée, H de Wit, AJ Wijkhuijs, C Locatelli, C Colombo, V Arolt, HA Drexhage, F Benedetti

Research output: Contribution to journalArticlepeer-review


INTRODUCTION: Bipolar Disorder (BD) is a severe psychiatric condition characterized by grey matter (GM) volumes reduction. Neurotrophic factors have been suggested to play a role in the neuroprogressive changes during the illness course. In particular peripheral brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in BD. The aim of our study was to investigate if serum levels of BDNF are associated with GM volumes in BD patients and healthy controls (HC). METHODS: We studied 36 inpatients affected by a major depressive episode in course of BD type I and 17 HC. Analysis of variance was performed to investigate the effect of diagnosis on GM volumes in the whole brain. Threshold for significance was P
Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalPsychiatrie et Psychobiologie
Issue number24
Publication statusPublished - 2017

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