Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state

A blinded retrospective multi-centric study

Sergio Bagnato, Luigi Minafra, Valentina Bravatà, Cristina Boccagni, Antonino Sant'Angelo, Alberto Castiglione, Maria Andriolo, Lucia Francesca Lucca, Antonio De Tanti, Caterina Pistarini, Rita Formisano, Giuliano Dolce, Cecilia Gelfi, Giuseppe Galardi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life. Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. A common polymorphism in the BDNF gene-BDNF Val66Met (referred to herein as BDNFMet)-impairs cognitive function in healthy subjects. The aim of this study was to determine whether the BDNFMet polymorphism plays a role in the recovery of consciousness and cognitive functions in patients in a VS after a TBI. Fifty-three patients in a VS 1 month after a TBI were included in the study and genotyped for the BDNFMet polymorphism. Scores of levels of cognitive functioning (LCF) at 1, 3, 6, and 12 months post-TBI were retrospectively compared in patients without (Val group), and with (Met group), the BDNFMet polymorphism. The BDNF Met polymorphism was detected in 20 out of the 53 patients. The mean LCF scores in the Val and Met groups were 1.6±0.5 and 1.4±0.5 at 1 month, 2.3±0.7 and 2.5±1.2 at 3 months, 3.3±1.7 and 3.5±1.7 at 6 months, and 4±1.9 and 3.9±1.8 at 12 months, respectively (p>0.05). The percentages of patients in the Val and Met groups who emerged from the VS were 36.4% and 30% at 3 months, 66.3% and 70% at 6 months, and 70% and 87.5% at 12 months (p>0.05), respectively. These findings provide evidence that the BDNFMet polymorphism is not involved in cognitive improvement in patients with a VS following TBI. Future studies should focus on the role of other BDNF polymorphisms in the recovery from a VS.

Original languageEnglish
Pages (from-to)2050-2059
Number of pages10
JournalJournal of Neurotrauma
Volume29
Issue number11
DOIs
Publication statusPublished - Jul 20 2012

Fingerprint

Persistent Vegetative State
Brain-Derived Neurotrophic Factor
Cognition
Neuronal Plasticity
Recovery of Function
Nerve Growth Factors
Consciousness
Healthy Volunteers
Traumatic Brain Injury
Brain
Genes

Keywords

  • disorders of consciousness
  • genetic factors
  • levels of cognitive functioning
  • traumatic brain injury
  • vegetative state

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state : A blinded retrospective multi-centric study. / Bagnato, Sergio; Minafra, Luigi; Bravatà, Valentina; Boccagni, Cristina; Sant'Angelo, Antonino; Castiglione, Alberto; Andriolo, Maria; Lucca, Lucia Francesca; De Tanti, Antonio; Pistarini, Caterina; Formisano, Rita; Dolce, Giuliano; Gelfi, Cecilia; Galardi, Giuseppe.

In: Journal of Neurotrauma, Vol. 29, No. 11, 20.07.2012, p. 2050-2059.

Research output: Contribution to journalArticle

Bagnato, S, Minafra, L, Bravatà, V, Boccagni, C, Sant'Angelo, A, Castiglione, A, Andriolo, M, Lucca, LF, De Tanti, A, Pistarini, C, Formisano, R, Dolce, G, Gelfi, C & Galardi, G 2012, 'Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: A blinded retrospective multi-centric study', Journal of Neurotrauma, vol. 29, no. 11, pp. 2050-2059. https://doi.org/10.1089/neu.2011.2184
Bagnato, Sergio ; Minafra, Luigi ; Bravatà, Valentina ; Boccagni, Cristina ; Sant'Angelo, Antonino ; Castiglione, Alberto ; Andriolo, Maria ; Lucca, Lucia Francesca ; De Tanti, Antonio ; Pistarini, Caterina ; Formisano, Rita ; Dolce, Giuliano ; Gelfi, Cecilia ; Galardi, Giuseppe. / Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state : A blinded retrospective multi-centric study. In: Journal of Neurotrauma. 2012 ; Vol. 29, No. 11. pp. 2050-2059.
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abstract = "Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life. Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. A common polymorphism in the BDNF gene-BDNF Val66Met (referred to herein as BDNFMet)-impairs cognitive function in healthy subjects. The aim of this study was to determine whether the BDNFMet polymorphism plays a role in the recovery of consciousness and cognitive functions in patients in a VS after a TBI. Fifty-three patients in a VS 1 month after a TBI were included in the study and genotyped for the BDNFMet polymorphism. Scores of levels of cognitive functioning (LCF) at 1, 3, 6, and 12 months post-TBI were retrospectively compared in patients without (Val group), and with (Met group), the BDNFMet polymorphism. The BDNF Met polymorphism was detected in 20 out of the 53 patients. The mean LCF scores in the Val and Met groups were 1.6±0.5 and 1.4±0.5 at 1 month, 2.3±0.7 and 2.5±1.2 at 3 months, 3.3±1.7 and 3.5±1.7 at 6 months, and 4±1.9 and 3.9±1.8 at 12 months, respectively (p>0.05). The percentages of patients in the Val and Met groups who emerged from the VS were 36.4{\%} and 30{\%} at 3 months, 66.3{\%} and 70{\%} at 6 months, and 70{\%} and 87.5{\%} at 12 months (p>0.05), respectively. These findings provide evidence that the BDNFMet polymorphism is not involved in cognitive improvement in patients with a VS following TBI. Future studies should focus on the role of other BDNF polymorphisms in the recovery from a VS.",
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