Brain development and perinatal vulnerability to cerebral damage

Luca A. Ramenghi, Monica Fumagalli, Veena Supramaniam

Research output: Chapter in Book/Report/Conference proceedingChapter


The recent exponential rise in detailed magnetic resonance (MR) imaging studies has emphasized the concept of gestationally determined regional vulnerability in the brain: the site and nature of the injury sustained being determined by a combination of the characteristics of the insult, the specific tissue and cell vulnerability and the gestation of the infant. The type of insult may also be partly dependent on gestation. However, it is now known that acute perinatal hypoxic ischemic events, previously considered characteristic for the term born neonate presenting with hypoxic-ischemic encephalopathy (HIE), may occur at earlier points in gestation [1, 2]. Nevertheless, such events occur less often in the infant born preterm where lesions develop in similar brain regions and in other areas characteristically more vulnerable in more premature babies (Fig. 127.1). Similarly, white matter (WM) lesions, which are considered the hallmark of injury to the preterm brain because they are characteristic of perinatal injury relating to inflammation, infection or hypoglycemia in the term brain, may also occur in a small percentage of neonates with an encephalopathy (Fig. 127.2) [3].

Original languageEnglish
Title of host publicationNeonatology: A Practical Approach to Neonatal Diseases
PublisherSpringer-Verlag Milan
Number of pages12
ISBN (Print)9788847014053, 9788847014046
Publication statusPublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Brain development and perinatal vulnerability to cerebral damage'. Together they form a unique fingerprint.

Cite this