Abstract
A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.
| Original language | English |
|---|---|
| Pages (from-to) | 153-160 |
| Number of pages | 8 |
| Journal | Psychopharmacology |
| Volume | 132 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1997 |
Fingerprint
Keywords
- Autoreceptor
- Behavioural genetics
- BXD RI strains
- D2 receptors
- Genetic liability
- Nucleus accumbens
- Psychopathology
- Stress
- Ventral tegmental area
ASJC Scopus subject areas
- Pharmacology
Cite this
Brain dopamine receptor plasticity : Testing a diathesis-stress hypothesis in an animal model. / Cabib, Simona; Oliverio, Alberto; Ventura, Rossella; Lucchese, Franco; Puglisi-Allegra, Stefano.
In: Psychopharmacology, Vol. 132, No. 2, 1997, p. 153-160.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain dopamine receptor plasticity
T2 - Testing a diathesis-stress hypothesis in an animal model
AU - Cabib, Simona
AU - Oliverio, Alberto
AU - Ventura, Rossella
AU - Lucchese, Franco
AU - Puglisi-Allegra, Stefano
PY - 1997
Y1 - 1997
N2 - A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.
AB - A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.
KW - Autoreceptor
KW - Behavioural genetics
KW - BXD RI strains
KW - D2 receptors
KW - Genetic liability
KW - Nucleus accumbens
KW - Psychopathology
KW - Stress
KW - Ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=0030743304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030743304&partnerID=8YFLogxK
U2 - 10.1007/s002130050331
DO - 10.1007/s002130050331
M3 - Article
VL - 132
SP - 153
EP - 160
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2
ER -