Brain dopamine receptor plasticity

Testing a diathesis-stress hypothesis in an animal model

Simona Cabib, Alberto Oliverio, Rossella Ventura, Franco Lucchese, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalPsychopharmacology
Volume132
Issue number2
DOIs
Publication statusPublished - 1997

Fingerprint

Disease Susceptibility
Dopamine Receptors
Neuronal Plasticity
Animal Models
Brain
Inbred DBA Mouse
Quantitative Trait Loci
Psychopathology
Inbred C57BL Mouse
Genes
Dopamine
Pathology

Keywords

  • Autoreceptor
  • Behavioural genetics
  • BXD RI strains
  • D2 receptors
  • Genetic liability
  • Nucleus accumbens
  • Psychopathology
  • Stress
  • Ventral tegmental area

ASJC Scopus subject areas

  • Pharmacology

Cite this

Brain dopamine receptor plasticity : Testing a diathesis-stress hypothesis in an animal model. / Cabib, Simona; Oliverio, Alberto; Ventura, Rossella; Lucchese, Franco; Puglisi-Allegra, Stefano.

In: Psychopharmacology, Vol. 132, No. 2, 1997, p. 153-160.

Research output: Contribution to journalArticle

@article{3812a1b08fd343dda2af772fcb6ad412,
title = "Brain dopamine receptor plasticity: Testing a diathesis-stress hypothesis in an animal model",
abstract = "A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.",
keywords = "Autoreceptor, Behavioural genetics, BXD RI strains, D2 receptors, Genetic liability, Nucleus accumbens, Psychopathology, Stress, Ventral tegmental area",
author = "Simona Cabib and Alberto Oliverio and Rossella Ventura and Franco Lucchese and Stefano Puglisi-Allegra",
year = "1997",
doi = "10.1007/s002130050331",
language = "English",
volume = "132",
pages = "153--160",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Brain dopamine receptor plasticity

T2 - Testing a diathesis-stress hypothesis in an animal model

AU - Cabib, Simona

AU - Oliverio, Alberto

AU - Ventura, Rossella

AU - Lucchese, Franco

AU - Puglisi-Allegra, Stefano

PY - 1997

Y1 - 1997

N2 - A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.

AB - A wealth of clinical data supports a major role of genetic liability as well as of altered brain dopamine (DA) functioning in different types of behavioural disturbances. Genetic influence on behaviour involves multiple genes, rather than one or two major genes, as well as non-genetic sources of variance. Thus, in recent years, increasing attention has been devoted to the involvement of stressful experiences (life events) in the development and expression of psychopathology. Moreover, a diathesis-stress hypothesis has been proposed, which suggests that the environmental factors (stress) are not specific for a given pathology, whereas genetic factors (diathesis) are. Results obtained in an animal model offer support to this hypothesis. Indeed, mice of the C57BL/6 and DBA/2 inbred strains are equally susceptible to stress but develop different behavioural disturbances related to different alterations of brain DA receptors. Moreover, quantitative trait loci (QTL) associations in the C57 (B) x DBA (D) recombinant inbred (RI) strains indicate a number of provisional QTLs influencing the behavioural effect of stress. Finally, the results of this analysis suggest the involvement of regulatory factors related to stress response and neural or synaptic plasticity in the control of brain DA receptor plasticity.

KW - Autoreceptor

KW - Behavioural genetics

KW - BXD RI strains

KW - D2 receptors

KW - Genetic liability

KW - Nucleus accumbens

KW - Psychopathology

KW - Stress

KW - Ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=0030743304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030743304&partnerID=8YFLogxK

U2 - 10.1007/s002130050331

DO - 10.1007/s002130050331

M3 - Article

VL - 132

SP - 153

EP - 160

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 2

ER -