Abstract
Clinical, neuropsychological and neuropsychophysiological data (Q-EEG, ERPs and CNV/RT activity) were obtained from 24 patients who had more or less severe presenile primary cognitive decline without depression, and compared with similar data from 10 age-matched healthy volunteers (mean age, 59.4 years). All of the patients (15 M and 9 F; mean age 59.6 years) were selected according to the DSM III-R, ICD-10 and NINCDS-ADRDA criteria and underwent CT and MRI scanning, in addition to a standard clinical examination, a battery of psychometric tests, spectral EEG, and bit-mapped CNV complex and RT to S2 analyses. Twelve of the 24 patients presented an initial presenile idiopathic cognitive decline (PICD) but did not wholly fulfil the clinical and neuropsychological criteria for primary dementia or for a diagnosis of probable AD; the remaining 12 patients showed characteristic clinical signs and symptoms of a very probable early stage of presenile Alzheimer-type dementia (PAD). ANOVA, correlational and discriminant analyses of the neuropsychological test scores, and the neurophysiological and RT to S2 data revealed 22 highest-ranked between-group discriminant factors (all with a significance level of p
| Original language | English |
|---|---|
| Pages (from-to) | 341-376 |
| Number of pages | 36 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jun 1995 |
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Keywords
- CNV complex
- ERPs
- presenile Alzheimer's disease
- presenile dementia
- psychometrics
- Q-EEG
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Brain electrical activity (quantitative EEG and bit-mapping neurocognitive CNV components), psychometrics and clinical findings in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia. / Zappoli, R.; Versari, A.; Paganini, M.; Arnetoli, G.; Muscas, G. C.; Gangemi, P. F.; Arneodo, M. G.; Poggiolini, D.; Zappoli, F.; Battaglia, A.
In: Italian Journal of Neurological Sciences, Vol. 16, No. 5, 06.1995, p. 341-376.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brain electrical activity (quantitative EEG and bit-mapping neurocognitive CNV components), psychometrics and clinical findings in presenile subjects with initial mild cognitive decline or probable Alzheimer-type dementia
AU - Zappoli, R.
AU - Versari, A.
AU - Paganini, M.
AU - Arnetoli, G.
AU - Muscas, G. C.
AU - Gangemi, P. F.
AU - Arneodo, M. G.
AU - Poggiolini, D.
AU - Zappoli, F.
AU - Battaglia, A.
PY - 1995/6
Y1 - 1995/6
N2 - Clinical, neuropsychological and neuropsychophysiological data (Q-EEG, ERPs and CNV/RT activity) were obtained from 24 patients who had more or less severe presenile primary cognitive decline without depression, and compared with similar data from 10 age-matched healthy volunteers (mean age, 59.4 years). All of the patients (15 M and 9 F; mean age 59.6 years) were selected according to the DSM III-R, ICD-10 and NINCDS-ADRDA criteria and underwent CT and MRI scanning, in addition to a standard clinical examination, a battery of psychometric tests, spectral EEG, and bit-mapped CNV complex and RT to S2 analyses. Twelve of the 24 patients presented an initial presenile idiopathic cognitive decline (PICD) but did not wholly fulfil the clinical and neuropsychological criteria for primary dementia or for a diagnosis of probable AD; the remaining 12 patients showed characteristic clinical signs and symptoms of a very probable early stage of presenile Alzheimer-type dementia (PAD). ANOVA, correlational and discriminant analyses of the neuropsychological test scores, and the neurophysiological and RT to S2 data revealed 22 highest-ranked between-group discriminant factors (all with a significance level of p
AB - Clinical, neuropsychological and neuropsychophysiological data (Q-EEG, ERPs and CNV/RT activity) were obtained from 24 patients who had more or less severe presenile primary cognitive decline without depression, and compared with similar data from 10 age-matched healthy volunteers (mean age, 59.4 years). All of the patients (15 M and 9 F; mean age 59.6 years) were selected according to the DSM III-R, ICD-10 and NINCDS-ADRDA criteria and underwent CT and MRI scanning, in addition to a standard clinical examination, a battery of psychometric tests, spectral EEG, and bit-mapped CNV complex and RT to S2 analyses. Twelve of the 24 patients presented an initial presenile idiopathic cognitive decline (PICD) but did not wholly fulfil the clinical and neuropsychological criteria for primary dementia or for a diagnosis of probable AD; the remaining 12 patients showed characteristic clinical signs and symptoms of a very probable early stage of presenile Alzheimer-type dementia (PAD). ANOVA, correlational and discriminant analyses of the neuropsychological test scores, and the neurophysiological and RT to S2 data revealed 22 highest-ranked between-group discriminant factors (all with a significance level of p
KW - CNV complex
KW - ERPs
KW - presenile Alzheimer's disease
KW - presenile dementia
KW - psychometrics
KW - Q-EEG
UR - http://www.scopus.com/inward/record.url?scp=34249758668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249758668&partnerID=8YFLogxK
U2 - 10.1007/BF02229172
DO - 10.1007/BF02229172
M3 - Article
AN - SCOPUS:34249758668
VL - 16
SP - 341
EP - 376
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 5
ER -