Brain energy metabolism studied by 31P-MR spectroscopy in a case of migraine with prolonged aura

T. Sacquegna, R. Lodi, P. De Carolis, P. Tinuper, P. Cortelli, P. Zaniol, R. Funicello, P. Montagna, B. Barbiroli

Research output: Contribution to journalArticlepeer-review

Abstract

The brain and skeletal muscle oxidative metabolism of a patient with prolonged aura was studied by phosphorus magnetic resonance spectroscopy. We found that the phosphocreatine to ATP ratio in brain was reduced, while the inorganic phosphate to phosphocreatine ratio and the calculated ADP concentration were increased. The phosphorylation potential and percentage of maximal rate of ATP synthesis were also altered. Intracellular pH and inorganic phosphate concentration were normal. In muscle we found a low post-exercise recovery of phosphocreatine. These data indicate an impairment of energy oxidative metabolism both in brain and muscle.

Original languageEnglish
Pages (from-to)376-380
Number of pages5
JournalActa Neurologica Scandinavica
Volume86
Issue number4
Publication statusPublished - 1992

Keywords

  • P-MR spectroscopy
  • brain energy metabolism
  • migraine aura
  • muscle energy metabolism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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